Zum Einfluss von Vitamin D und Kalzium auf die muskuloskelettale Gesundheit

Zusammenfassung

Bei älteren Menschen (etwa ab dem 65. Lebensjahr) kann eine Supplementation mit Vitamin D (800–1200 I.E. pro Tag) und Kalzium (800–1200 mg pro Tag) dazu beitragen, Stürze und sturzbedingte Knochenbrüche im Sinne einer Primärprävention zu verhindern. Inzwischen liegen hierzu zahlreiche randomisierte, placebokontrollierte und prospektive Doppelblindstudien vor, die zumindest für die Verminderung der Sturzrate eine Meta-Analyse erlauben, so dass nach den Kriterien einer auf Evidenz basierenden Medizin im Hinblick auf die Sturzprävention sowie für die Primärprävention von Schenkelhalsfrakturen von einer Evidenzstärke Grad Ia auszugehen ist, wobei die Wirkung bei Frauen mit einem 25-Hydroxy-Vitamin-D₃-Serumspiegel unter 50 nmol/l besonders gut dokumentiert ist.

Summary

During the last five years several randomised, prospective, placebo-controlled clinical trials have been documented thata supplementation with vitamin D (800–1200 I.U. per day) together with calcium (800–1200 mg per day) may reduce the risk of falls and fall-related fractures in the elderly. This is especially the case in elderly women 65 years of age or older witha serum 25-hydroxy-vitamin D3 level below 50 nmol/l. Based on the results ofa recently published meta-analysis involving more than 10,000 participants the grade of evidence according to the Oxford centre of evidence-based medicine is Ia with respect to the primary prevention of falls in the elderly population.

Schlüsselwörter

Vitamin D - Osteoporose - Stürze - Frakturen

Keywords

Vitamin D - osteoporosis - falls - fractures

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