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Adipositas - Ursachen, Folgeerkrankungen, Therapie 2015; 09(04): 210-216
DOI: 10.1055/s-0037-1618940
Übersichtsarbeit
Schattauer GmbH

Gibt es die Adaptive Thermogenese?

Überlegungen zu “Sparstoffwechsel” und EnergiebilanzDoes adaptive thermogenesis exist?Thoughts on reduced metabolism and energy balance
M. J. Müller
1   Institut für Humanernährung und Lebensmittelkunde, Christian-Albrechts-Universität zu Kiel
,
J. Enderle
1   Institut für Humanernährung und Lebensmittelkunde, Christian-Albrechts-Universität zu Kiel
,
W. Braun
1   Institut für Humanernährung und Lebensmittelkunde, Christian-Albrechts-Universität zu Kiel
,
M. Pourhassan
1   Institut für Humanernährung und Lebensmittelkunde, Christian-Albrechts-Universität zu Kiel
,
A. Bosy-Westphal
2   Institut für Ernährungsmedizin, Universität Hohenheim, Stuttgart
› Institutsangaben
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Publikationsverlauf

Publikationsdatum:
22. Dezember 2017 (online)

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Zusammenfassung

Reduktionsdiäten und Gewichtsverlust bewirken eine Drosselung des zellulären Energieverbrauchs; diese wird als Adaptive Thermogenese (AT) bezeichnet. Bei kontrollierter Kalorienrestriktion erklärt die AT anteilig die nichtlineare Gewichtsabnahme. Vice versa begünstigt ein niedriger Energieverbrauch die Gewichtszunahme in der Ernährungstherapie von Patientinnen mit Anorexia nervosa. Das Ausmaß der AT beträgt etwa 100 kcal/Tag. Die AT ist reproduzierbar, die inter-individuelle Varianz der Stoffwechselanpassung ist allerdings hoch, während Gewichtsreduktion ist sie bei bis zu 60 % der Menschen nachweisbar. Die AT ist unabhängig von der Strategie der Gewichtsabnahme und innerhalb von drei Tagen Kalorienrestriktion messbar, während einer Diät und bei nachhaltiger Gewichtsreduktion bleibt sie erhalten. Nach Gewichtszunahme ist die AT jedoch innerhalb von zwei Wochen reversibel. Der Abfall der Insulinsekretion und die in “frühen” Stadien der Reduktionsdiät durch Mobilisation der hepatischen Glykogenspeicher erklärte negative Flüssigkeitsbilanz sind zur AT assoziiert. Demgegenüber zeigen die bei Gewichtsabnahme reduzierten Plasmaspiegel von Leptin und Triiodothyronin sowie die niedrige Aktivität des sympathischen Nervensystems eine Beziehung zum Erhalt des reduzierten Körpergewichts, nicht aber zur Regulation der Adaptiven Thermogenese.

Summary

Caloric restriction (CR) and weight loss result in a decrease in cellular energy expenditure, i.e. the so-called adaptive thermogenesis (AT). During controlled CR AT adds to explain the non-linear weight loss. Vice versa AT may add to weight gain in feeding underweight patients with anorexia nervosa. AT is about 100 kcal/d, it is reproducible but the interindividual variance is high. During CR AT becomes measurable within three days and can be detected in up to 60 % of subjects. AT is independent of the weight loss strategy. AT persisted after stabilization of reduced body weight. With re-feeding AT is reversible within two weeks. During CR AT is associated with decreases in insulin secretion and negative fluid balance due to mobilization of hepatic glycogen. Negative energy balance associated decreases in plasma concentrations of leptin and triiodothyronine as well as reduced activity of the sympathetic nervous system reflect maintenance of reduced body weight rather than regulation of AT.

Schlüsselwörter

Energiebilanz - Energieverbrauch - Körperzusammensetzung - sympathisches Nervensystem - Schilddrüsenhormone - Leptin

Keywords

Energy balance - energy expenditure - body composition - sympathetic nervous system - thyroid hormones - leptin
 

  • Literatur

  • 1 Bosy-Westphal A, Kossel E, Goele K. et al. Contribution of individual organ mass loss to weight loss-associated decline in resting energy expenditure. Am J Clin Nutr 2009; 90: 993-1001.
    CrossrefPubMedSuche in Google Scholar
  • 2 Bosy-Westphal A, Braun W. et al. Issues in characterizing resting energy expenditure in obesity and after weight loss. Front Physiol 2013; 25: 47.
    PubMedSuche in Google Scholar
  • 3 Bosy-Westphal A, Schautz B, Lagerpusch M. et al. Effect of weight loss and regain on adipose tissue distribution, composition of lean mass and resting energy expenditure in young overweight and obese adults. Int J Obes 2013; 37: 1371-1377.
    CrossrefPubMedSuche in Google Scholar
  • 4 Bosy-Westphal A, Kahlhöfer J. et al. Deep body composition phenotyping during weight cycling: relevance to metabolic efficiency and metabolic risk. Obes Rev 2015; 16 Suppl 1: 36-44.
    PubMedSuche in Google Scholar
  • 5 Butte NF, Brandt ML. et al. Energetic adaptations persist after bariatric surgery in severely obese adolescents. Obesity 2015; 23: 591-601.
    CrossrefPubMedSuche in Google Scholar
  • 6 Cahill Jr GF. Starvation in man. New Engl J Med 1970; 282: 668-675.
    CrossrefPubMedSuche in Google Scholar
  • 7 Dulloo AG 1, Jacquet J, Girardier L. Autoregulation of body composition during weight recovery in human: the Minnesota Experiment revisited. Int J Obes 1996; 20: 393-405.
    PubMedSuche in Google Scholar
  • 8 Dulloo AG, Jacquet J. An adipose-specific control of thermogenesis in body weight regulation. Int J Obes 2001; 25 Suppl 5: S22-29.
    PubMedSuche in Google Scholar
  • 9 Dulloo AG, Jacquet J, Montani J-P, Schutz Y. Adaptive thermogenesis in human body weight regulation: more a concept than a measurable entity?. Obes rev 2012; 13 Suppl 2: 105-121.
    PubMedSuche in Google Scholar
  • 10 Goele K, Bosy-Westphal A, Rumcker B. et al. Influence of changes in body composition and adaptive thermogenesis on the difference between measured and predicted weight loss in obese women. Obes Facts 2009; 02: 105-109.
    PubMedSuche in Google Scholar
  • 11 Haas V, Onur S, Paul T. et al. Leptin and body weight regulation in patients with anorexia nervosa before and during weight recovery. Am J Clin Nutr 2005; 81: 889-896.
    CrossrefPubMedSuche in Google Scholar
  • 12 Hall KD. Predicting metabolic adaptation, body weight change, and energy intake in humans. Am J Physiol Endocrin Metab 2010; 298: E449-E466.
    PubMedSuche in Google Scholar
  • 13 Hopkins M, Gibbons C. et al. The adaptive metabolic response to exercise-induced weight loss influences both energy expenditure and energy intake. Eur J Clin Nutr 2014; 68: 581-586.
    CrossrefPubMedSuche in Google Scholar
  • 14 Keys A, Brozek J, Henschel A. et al. The Biology of Human Starvation. Minneapolis: University of Minnesota Press; 1950
    Suche in Google Scholar
  • 15 Knuth ND, Johannsen DL, Tamboli RA. et al. Metabolic adaptation following massive weight loss is related to the degree of energy imbalance and changes in circulating leptin. Obesity. 2014 online publ 19 Sep, DOI: 10.1002/oby.20900.
    PubMedSuche in Google Scholar
  • 16 Johannsen DL, Knuth ND, Huizenga R. et al. Metabolic slowing with massive weight loss despite preservation of fat free mass. J Clin Endocrin Metab 2012; 97: 3489-3496.
    PubMedSuche in Google Scholar
  • 17 Leibel RL, Rosenbaum M, Hirsch J. Changes in energy expenditure resulting from altered body weight. New Engl J Med 1995; 332: 621-628.
    CrossrefPubMedSuche in Google Scholar
  • 18 Leibel RL. Molecular physiology of weight regulation in mice and humans. Int J Obes 2008; 32 Suppl 7: S98-S108.
    PubMedSuche in Google Scholar
  • 19 Müller MJ, Bosy-Westphal A, Heymsfield SB. Is there evidence for a set point that regulates human body weight?. F1000 Med Rep 2010; 02: 59.
    PubMedSuche in Google Scholar
  • 20 Müller MJ, Bosy-Westphal A. Adaptive thermogenesis with weight loss in humans. Obesity 2013; 21: 218-228.
    CrossrefPubMedSuche in Google Scholar
  • 21 Müller MJ, Wang Z, Heymsfield SB. et al. Advances in the understanding of specific metabolic rates of major organs and tissues in humans. Curr Opin Clin Nutr Metab Care 2013; 16: 501-508.
    PubMedSuche in Google Scholar
  • 22 Müller MJ, Enderle J. et al. Metabolic adaptation to caloric restriction and subsequent refeeding: the Minnesota Starvation Experiment revisited. Am J Clin Nutr 2015; 102: 807-819.
    CrossrefPubMedSuche in Google Scholar
  • 23 Pourhassan M, Glüer C-C, Bosy-Westphal A. et al. Effect of Different Degrees of Weight Loss on Detailed Body Composition and Insulin Resistance. 37th ESPEN, Lissabon, 2015, abstr. SUN-LB033.
    PubMed
  • 24 Prentice AM, Hennig BJ, Fulford AJ. Evolutionary origins of the obesity epidemic: natural selection of thrifty genes or genetic drift following predation release?. Int J Obes 2008; 32: 1607-1610.
    CrossrefPubMedSuche in Google Scholar
  • 25 Rosenbaum M, Goldsmith R. et al. Low-dose leptin reverses skeletal muscle, autonomic, and neuroendocrine adaptations to maintenance of reduced weight. J Clin Invest 2005; 115: 3579-3586.
    CrossrefPubMedSuche in Google Scholar
  • 26 Rosenbaum M, Hirsch J, Gallagher DA, Leibel R. Long-term persistence of adaptive thermogenesis in subjects who have maintained a reduced body weight. Am J Clin Nutr 2008; 88: 906-912.
    CrossrefPubMedSuche in Google Scholar
  • 27 Rosenbaum M, Leibel RL. Adaptive thermogenesis in humans. Int J Obes 2010; 34: S47-S55.
    CrossrefPubMedSuche in Google Scholar
  • 28 Schwartz A, Kuk JL, Lamothe G, Doucet E. Greater than predicted decrease in resting energy expenditure and weight loss: results from a systematic review. Obesity 2012; 20: 2307-2310.
    CrossrefPubMedSuche in Google Scholar
  • 29 Siervo M, Faber P, Lara J. et al. Imposed extent of weight loss in obese men and adaptive changes in resting and total energy expenditure. Metabolism 2015; 64: 896-904.
    CrossrefPubMedSuche in Google Scholar
  • 30 Tremblay A, Chaput J-P. Adaptive reduction in thermogenesis and resistance to lose fat in obese men. Br J Nutr 2009; 102: 488-492.
    CrossrefPubMedSuche in Google Scholar
  • 31 Tremblay A, Royer M-M, Chaput J-P, Doucet E. Adaptive thermogenesis can make the difference in the ability of obese individuals to lose body weight. Int J Obes 2013; 37: 759-764.
    CrossrefPubMedSuche in Google Scholar
  • 32 Tseng Y-H. et al. Cellular bioenergetics as a target for obesity treatment. Nat Rev 2010; 09: 465-481.
    PubMedSuche in Google Scholar
  • 33 Weinsier R. et al. Do adaptive changes in metabolic rate favor weight regain in weight-reduced individuals?. Am J Clin Nutr 2000; 72: 1088-1094.
    CrossrefPubMedSuche in Google Scholar
  • 34 Weyer C, Vozarova B, Ravussin E, Tataranni PA. Changes in energy metabolism in response to 48 h of overfeeding and fasting in Caucasians and Pima Indians. Int J Obes 2001; 25: 593-600.
    CrossrefPubMedSuche in Google Scholar