CC BY-NC-ND 4.0 · Homeopathy 2018; 107(01): 019-031
DOI: 10.1055/s-0037-1617448
Original Research Article
The Faculty of Homeopathy

Degree of Response to Homeopathic Potencies Correlates with Dipole Moment Size in Molecular Detectors: Implications for Understanding the Fundamental Nature of Serially Diluted and Succussed Solutions

Steven J. Cartwright
1   DiagnOx Laboratory, Cherwell Innovation Centre, Upper Heyford, Oxon, United Kingdom
› Author Affiliations
Further Information

Publication History

14 September 2017

30 November 2017

Publication Date:
23 January 2018 (online)

Abstract

Background The use of solvatochromic dyes to investigate homeopathic potencies holds out the promise of understanding the nature of serially succussed and diluted solutions at a fundamental physicochemical level. Recent studies have shown that a range of different dyes interact with potencies and, moreover, the nature of the interaction is beginning to allow certain specific characteristics of potencies to be delineated.

Aims and Methods The study reported in this article takes previous investigations further and aims to understand more about the nature of the interaction between potencies and solvatochromic dyes. To this end, the UV-visible spectra of a wide range of potential detectors of potencies have been examined using methodologies previously described.

Results Results presented demonstrate that solvatochromic dyes are a sub-group of a larger class of compounds capable of demonstrating interactions with potencies. In particular, amino acids containing an aromatic bridge also show marked optical changes in the presence of potencies. Several specific features of molecular detectors can now be shown to be necessary for significant interactions with homeopathic potencies. These include systems with a large dipole moment, electron delocalisation, polarizability and molecular rigidity.

Conclusions Analysis of the optical changes occurring on interaction with potencies suggests that in all cases potencies increase the polarity of molecular detectors to a degree that correlates with the size of the compound's permanent or ground dipole moment. These results can be explained by inferring that potencies themselves have polarity. Possible candidates for the identity of potencies, based on these and previously reported results, are discussed.

 
  • References

  • 1 Cartwright SJ. Solvatochromic dyes detect the presence of homeopathic potencies. Homeopathy 2016; 105: 55-65
  • 2 Cartwright SJ. Interaction of homeopathic potencies with the water soluble solvatochromic dye bis-dimethylaminofuchsone. Part 1: pH studies. Homeopathy 2017; 106: 37-46
  • 3 Reichardt C, Welton T. Solvent effects on the absorption spectra of organic compounds. In Solvents and Solvent Effects in Organic Chemistry. 4th ed. Weinheim: Wiley-VCH; 2011: 365-367
  • 4 Thayer MP, McGuire C, Stennett EM. , et al. pH dependent spectral properties of para-aminobenzoic acid and its derivatives. Spectrochim Acta A Mol Biomol Spectrosc 2011; 84: 227-232
  • 5 Halpern A, Ramachadran BR. The photophysics of ρ-aminobenzoic acid. Photochemistry and Photobiology 1995; 62: 686-691
  • 6 Gainer A, Stevens JS, Suljoti E. , et al. The structure of ρ-aminobenzoic acid in water: studies combining UV-vis, NEXAFS and RIXS spectroscopies. 16th International Conference on X-ray absorption fine structure (XAFS16); Journal of physics conference series 2016; 712: 1-4
  • 7 Jara GE, Solis CA, Gspooner NS. , et al. An experimental and TD-DFT theoretical study on the photophysical properties of methylene violet (Bernthsen). Dyes and Pigments 2015; 112: 341-351
  • 8 Ronzani F, Trivella A, Bordat P. , et al. Revisiting the photophysics and photochemistry of methylene violet (MV). J Photochem Photobiol Chem 2014; 284: 8-17
  • 9 Davis F, Higson S. Cyclodextrins. In Macrocycles Construction, Chemistry and Nanotechnology Applications. New York, NY: Wiley; 2011: 190-244
  • 10 Holt JS, Campitella A, Rich A, Young JL. Spectroscopic characterization of the binding and isomerization cycle of merocyanine with α-, β-, and γ-cyclodextrins. J Incl Phenom Macrocycl Chem 2008; 61: 251-258
  • 11 Steiner U, Abdel-Kader MH, Fischer P, Kramer HEA. Photochemical cis/trans isomerisation of a stilbazolium betaine. A protolytic/photochemical reaction cycle. J Am Chem Soc 1978; 10: 3190-3197
  • 12 Gonzalez D, Neilands O, Rezende MC. The solvatochromic behaviour of 2- and 4-pyridiniophenoxides. J Chem Soc, Perkin Trans 2 1999; 4: 713-717
  • 13 Albert A, Sergeant EP. Zwitterions (Dipolar Ions). In The Determination of Ionization Constants. London: Chapman and Hall; 1971: 76-81
  • 14 Perrin DD, Dempsey B, Serjeant EP. pKa Prediction for Organic Acids and Bases. London: Chapman and Hall; 1981
  • 15 Davis F, Higson S. Cucurbiturils. In Macrocycles: Construction, Chemistry and Nanotechnology Applications. New York, NY: Wiley; 2011: 325-368
  • 16 Minkin VI, Osipov OA, Zhdanov YA. Dipole Moments in Organic Chemistry. New York, NY: Springer; 1970
  • 17 Niewodniczański W, Bartkowiak W. Theoretical study of geometrical and nonlinear optical properties of pyridinium N-phenolate betaine dyes. J Mol Model 2007; 13: 793-800
  • 18 Wyn-Jones J, Gormally J. Aggregation Processes in Solution (Studies in Physical and Theoretical Chemistry 26). Amsterdam: Elsevier; 1983
  • 19 Hahnemann S. Organon of Medicine. 5th and 6th eds
  • 20 Meichsner J, Schmidt M, Schneider R, Wagner HE. Nonthermal Plasma: Chemistry and Physics. Boca Raton: CRC Press; 2013
  • 21 Nakayama K. Triboemission, triboplasma generation, and tribochemistry. In: Wang QJ, Chung YW. , eds. Encyclopedia of Tribology. New York, NY: Springer; 2013: 3750-3760
  • 22 Nikitenk SI. Plasma formation during acoustic cavitation: toward a new paradigm for sonochemistry. Adv Phys Chem 2014; 2014: 173878 http://dx.doi.org/10.1155/2014/173878
  • 23 Hibou F. Could the study of cavitation luminescence be useful in high dilution research?. Homeopathy 2017; 106: 181-190