Physiology of blood coagulation and fibrinolysis

K. T. Preissner

doi:10.1055/s-0037-1617175

Hämostaseologie, Table of Contents

Hamostaseologie 2008; 28(05): 259-271
DOI: 10.1055/s-0037-1617175

Hämostaseologie

Schattauer GmbH

Physiologie der Blutgerinnung und Fibrinolyse

BiochemiePhysiology of blood coagulation and fibrinolysisBiochemistry

K. T. Preissner

¹Institut für Biochemie, Fachbereich Medizin, Justus-Liebig-Universität, Gießen

› Author Affiliations

Abstract

Zusammenfassung

Die Prinzipien der Auslösemechanismen, Initiator- und Amplifikationsreaktionen der Blutgerinnung und Fibrinolyse werden dargestellt und in Zusammenhang mit Regulationskreisläufen der Hämostase diskutiert. Besonders der Charakter der zelloberflächenkontrollierten Aktivierungsund Inhibierungsreaktionen in Form der Multikomponenten- Enzymkomplexe erlaubt die endogene physiologische Kontrolle des Systems und ermöglicht bei Störungen der Hämostase eine therapeutische Intervention mit unterschiedlichen pro- und antikoagulatorischen Wirkstoffen.

Summary

The principles of initiator and amplifications reactions of blood coagulation and fibrinolysis will be presented and discussed in relation to various regulatory pathways of haemostasis. In particular, cell surface-dependent activation and inhibition reactions are characteristics of multicomponent enzyme complexes that also allow the endogenous control of the haemostasis system. The understanding of these relationships in complications of haemo stasis has lead to different strategies for the therapeutic intervention with pro- and anticoagulant substances.

Schlüsselwörter

Multi-Komponenten-Enzymkomplexe - Thrombin - Feedback- Regulation - Oberflächenreaktionen - Enzymkaskade - Inhibitoren - Gendefekte

Keywords

Multicomponent enzyme complexes - thrombin - feedback regulation - surface reactions - enzyme cascade - inhibitors - gene defects

Full Text

References

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