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DOI: 10.1055/s-0037-1617000
Direkte Thrombininhibition in der interventionellen Kardiologie
Die ACUITY-StudieDirect thrombin inhibition in interventional cardiologyThe ACUITY trialPublication History
Publication Date:
27 December 2017 (online)
Zusammenfassung
Der direkte Thrombininhibitor Bivalirudin wurde im Rahmen der ACUITY-Studie bei 13 819 Patienten mit akutem Nicht-ST-Elevations-Koronarsyndrom prospektiv randomisiert untersucht. Dabei wurden drei antithrombotische Therapieregime im Rahmen eines frühinvasiven Vorgehens verglichen: Heparin plus Glykoprotein-IIb/IIIaRezerptorinhibitor (GPI), Bivalirudin plus GPI und Bivalirudin als Montherapie. Bezogen auf den Endpunkt der ischämischen Ereignisse war Bivalirudin allein vergleichbar mit Heparin plus GPI bei signifikant verringerter Rate von Blutungskomplikationen.
Summary
The direct thrombin inhibitor bivalirudin was tested in the ACUITY Trial 13 819 patients with acute non-ST-segment elevation coronary syndrome in a prospective and randomized design. Three therapeutic regimens were compared in the context of an early invasive strategy: heparin plus glycoprotein IIb/IIIa inhibitor (GPI), bivalirudin plus GPI, or bivalirudin alone. Concerning the rate of ischaemic events bivalirudin alone was comparable to heparin plus GPI at a significantly lower rate of bleeding complications.
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Literatur
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