Localization of Blood Coagulation Factors In Situ in Pancreatic Carcinoma

Marek Z. Wojtukiewicz; Monika Rucinska; Leo R. Zacharski; Leszek Kozlowski; Lech Zimnoch; Zdzislaw Piotrowski; Bohdan J. Kudryk; Walter Kisiel

doi:10.1055/s-0037-1616744

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 2001; 86(06): 1416-1420
DOI: 10.1055/s-0037-1616744

Review Article

Schattauer GmbH

Localization of Blood Coagulation Factors In Situ in Pancreatic Carcinoma

Authors

Marek Z. Wojtukiewicz

¹Departments of Oncology
Monika Rucinska

¹Departments of Oncology
Leo R. Zacharski

⁴Dartmouth Medical School and the Department of Veterans Affairs Medical and Regional Office Center, White River Junction, Vermont, USA
Leszek Kozlowski

¹Departments of Oncology
Lech Zimnoch

²Pathological Anatomy
Zdzislaw Piotrowski

³Gastroenterologic Surgery, Medical Academy, Bialystok, Poland
Bohdan J. Kudryk

⁵Laboratory of Blood Coagulation Biochemistry, New York Blood Center, New York, USA
Walter Kisiel

⁶Department of Pathology, University of New Mexico, School of Medicine, Albuquerque, New Mexico, USA

Abstract

Summary

Blood coagulation is activated commonly in pancreatic carcinoma but the role of the tumor cell in this activation is undefined. Immunohistochemical procedures were applied to fixed sections of 22 cases of resected adenocarcinoma of the pancreas to determine the presence of components of coagulation and fibrinolysis pathways in situ. Tumor cell bodies stained for tissue factor; prothrombin; and factors VII, VIIIc, IX, X, XII, and subunit “a” of factor XIII. Fibrinogen existed throughout the tumor stroma, and tumor cells were surrounded by fibrin. Staining for tissue factor pathway inhibitor, and plasminogen activators was minimal and inconsistent. Plasminogen activator inhibitors -1, -2, and -3 were present in the tumor stroma, and on tumor cells and vascular endothelium. Extravascular coagulation activation exists associated with pancreatic carcinoma cells in situ that is apparently unopposed by naturally occurring inhibitors or the plasminogen activator-plasmin system. We postulate that such local coagulation activation may regulate growth of this malignancy. These findings provide a rationale for testing agents that modulate the blood coagulation/fibrinolytic system (that inhibit tumor growth in other settings) in pancreatic carcinoma.

Keywords

Pancreatic cancer - blood coagulation - fibrin

Full Text

References

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