RSS-Feed abonnieren
Bitte kopieren Sie die angezeigte URL und fügen sie dann in Ihren RSS-Reader ein.
https://www.thieme-connect.de/rss/thieme/de/10.1055-s-00035024.xml
PDF herunterladen
Thromb Haemost 2001; 86(04): 939-941
DOI: 10.1055/s-0037-1616513
DOI: 10.1055/s-0037-1616513
Commentary
The Endothelial Cell Protein C Receptor: A Candidate Genetic Risk Factor for Thrombosis
Autoren
Weitere Informationen
Publikationsverlauf
Publikationsdatum:
09. Dezember 2017 (online)
-
References
- 1 Esmon CT. The protein C anticoagulant pathway. Arterioscler Thromb 1992; 12: 135-45.
- 2 Simmonds RE, Lane DA. Regulation of coagulation. in Thrombosis and Hemorrhage. Loscalzo J, Schafer AI. eds. Baltimore: Williams and Wilkins; 1998: 45-76.
- 3 Lane DA, Mannucci PM, Bauer KA, Bertina RM, Bochkov NP, Boulyjenkov V, Chandy M, Dahlbäck B, Ginter EK, Miletich JP, Rosendaal FR, Seligsohn U. Inherited thrombophilia: part 1. Thromb Haemost 1996; 76: 651-62.
- 4 Lane DA, Mannucci PM, Bauer KA, Bertina RM, Bochkov NP, Boulyjenkov V, Chandy M, Dahlbäck B, Ginter EK, Miletich JP, Rosendaal FR, Seligsohn U. Inhertied thrombophilia: part 2. Thromb Haemost 1996; 76: 824-34.
- 5 Fukudome K, Esmon CT. Identification, cloning and regulation of a novel endothelial protein C/activated protein C receptor. J Biol Chem 1994; 269: 26486-91.
- 6 Fukudome K, Kurosawa S, Stearns-Kurosawa DJ, He X, Rezaie AR, Esmon CT. The endothelial cell protein C receptor: Cell surface expression and direct ligand binding by the soluble receptor. J Biol Chem 1996; 271: 17491-98.
- 7 Kurosawa S, Stearns-Kurosawa DJ, Hidari N, Esmon CT. Identification of functional endothelial cell protein C receptor in human plasma. J Clin Invest 1997; 100: 411-8.
- 8 Regan LM, Mollica JS, Rezaie AR, Esmon CT. The interaction between the endothelial cell protein C receptor and protein C is dicated by the γ-carboxyglutamic acid domain of protein C. J Biol Chem 1997; 272: 26279-84.
- 9 Regan LM, Stearns-Kurosawa DJ, Kurosawa S, Mollica J, Fukudome K, Esmon CT. The endothelial cell protein C receptor: Inhibition of activated protein C anticoagulant function without modulation of reaction with proteinase inhibitors. J Biol Chem 1996; 271: 17499-503.
- 10 Liaw PCY, Neuenschwander PF, Smirnov MD, Esmon CT. Mechanisms by which soluble endothelial cell protein C receptor modulates protein C and activated protein C function. J Biol Chem 2000; 275: 5447-52.
- 11 Stearns-Kurosawa DJ, Kurosawa S, Mollica JS, Ferrell GL, Esmon ET. The endothelial cell protein C receptor augments protein C activation by the thrombin-thrombomodulin complex. Proc Natl Acad Sci USA 1996; 93: 10212-16.
- 12 Fukudome K, Ye X, Tsuneyoshi N, Tokunaga O, Sugawara K, Mizokami H, Kimoto M. Activation mechanism of anticoagulant protein C in large blood vessels involving the endothelial cell protein C receptor. J Exp Med 1998; 187: 1029-35.
- 13 Xu J, Esmon NL, Esmon CT. Reconstitution of the human endothelial cell protein C receptor with thrombomodulin in phosphatidylcholine vesicles enhance protein C activation. J Biol Chem 1999; 274: 6704-10.
- 14 Taylor Jr FB, Peer GT, Lockhart MS, Ferrell G, Esmon CT. Endothelial cell protein C receptor plays an important role in protein C activation in vivo. Blood 2001; 97: 1685-8.
- 15 Esmon CT. The roles of protein C and thrombomodulin in the regulation of blood coagulation. J Biol Chem 1989; 264: 4743-6.
- 16 Laszik Z, Mitro A, Taylor FBJ, Ferrell G, Esmon CT. Human protein C receptor is present primarily on endothelium of large blood vessels; implications for the control of the protein C pathway. Circulation 1997; 96: 3633-40.
- 17 Taylor Jr FB, Stearns-Kurosawa DJ, Kurosawa S, Ferrell G, Chang ACK, Laszik Z, Kosanke S, Peer G, Esmon CT. The endothelial cell protein C receptor aids in host defense against Escherichia coli sepsis. Blood 2000; 95: 1680-6.
- 18 Gu JM, Katsuura Y, Ferrell GL, Grammas P, Esmon CT. Endotoxin and thrombin elevate rodent endothelial cell protein C receptor mRNA levels and increase receptor shedding in vivo. Blood 2000; 95: 1687-93.
- 19 Gu JM, Fukudomw K, Esmon CT. Characterizationand regulation of the 5′-flanking region of the murine endothelial protein C receptor gene. J Biol Chem 2000; 275: 12481-8.
- 20 Xu J, Qu D, Esmon NL, Esmon CT. Metalloproteolytic release of the endothelial cell protein C receptor. J Biol Chem 2000; 275: 6038-44.
- 21 Laiw PCY, Mather T, Oganesyan N, Ferrell GL, Esmon CT. Identification of the proten C/activated protein C binding sites on the endothelial cell protein C receptor: implications for a novel mode of ligand recognition by an MHC Class I-type receptor. J Biol Chem. 2000 in Press (MO10572200).
- 22 Fukudome K, Esmon CT. Molecular cloning and expression of murine and bovine endothelial cell protein C/activated protein C receptor (EPCR). J Biol Chem 1995; 270: 5571-7.
- 23 Simmonds RE, Lane DA. Structural and functional implications of the intron/exon organisation of the human endothelial cell protein C/activated protein C receptor (EPCR) gene. Comparison with the structure of CD1/Major Histocompatibility Complex α1 and α2 domains. Blood 1999; 94: 632-41.
- 24 Laing U, Rosen ED, Castellino FJ. Nucleotide structure and characterisation of the murine gene encoding the endothelial cell protein C receptor. Thromb Haemost 1999; 81: 585-8.
- 25 Villoutreix B, Blom AM, Dahlback B. Structural prediction and analysis of endothelial cell protein C/activated protein C receptor. Protein Engineering 1999; 12: 833-840.
- 26 Biguzzi E, Merati G, Liaw PCY, Bucciarelli P, Oganesyan N, Qu D, Gu JM, Fetiveau R, Esmon CT, Mannucci PM, Faioni EM. A 23bp insertion in the endothelial cell protein C receptor (EPCR) gene impairs EPCR function. Thromb Haemost 2001; 86: 945-8.