Thromb Haemost 2001; 86(05): 1292-1295
DOI: 10.1055/s-0037-1616064
Review Article
Schattauer GmbH

Magnesium Inhibits Arterial Thrombi after Vascular Injury in Rat: In Vivo Impairment of Coagulation

Luciana Mussoni
1  Department of Pharmacological Sciences, University of Milan, Milan, Italy
,
Luigi Sironi
1  Department of Pharmacological Sciences, University of Milan, Milan, Italy
,
Luca Tedeschi
1  Department of Pharmacological Sciences, University of Milan, Milan, Italy
,
Anna Maria Calvio
1  Department of Pharmacological Sciences, University of Milan, Milan, Italy
,
Susanna Colli
1  Department of Pharmacological Sciences, University of Milan, Milan, Italy
,
Elena Tremoli
1  Department of Pharmacological Sciences, University of Milan, Milan, Italy
› Author Affiliations
This work was supported in part by grants from the European Community (HIFMECH Study, BMH4-CT96-0272) and from the Italian Ministry of University and Scientific Research (MURST 40%).
Further Information

Publication History

Received 28 September 2000

Accepted after resubmission 18 July 2001

Publication Date:
13 December 2017 (online)

Summary

Magnesium deficiency is associated with a high frequency of cardiac arrhythmia, hypertension and sudden ischemic death. We investigated the in vivo effects of intravenous magnesium administration in a rat model of chemically induced (FeCl3) carotid thrombosis. The infusion of magnesium sulfate (MgSO4) before the topical application of FeCl3 prevented thrombus formation at concentrations of 0.3 M and 0.6 M, and delayed it even at 0.15 M. Similar results were obtained with MgCl2. The infusion of MgSO4 0.6 M seven minutes after FeCl3 application delayed but did not prevent thrombus formation. MgSO4 slightly reduced platelet aggregation ex vivo without affecting plasma clotting tests, but in vivo blood clotting time was markedly prolonged (tail transection method), thus indicating profoundly impaired coagulation. These data provide a rationale for the use of magnesium as an anti-thrombotic agent, but its pharmacological effect critically depends on the timing of administration.