Magnesium Inhibits Arterial Thrombi after Vascular Injury in Rat: In Vivo Impairment of CoagulationThis work was supported in part by grants from the European Community (HIFMECH Study, BMH4-CT96-0272) and from the Italian Ministry of University and Scientific Research (MURST 40%).
28 September 2000
Accepted after resubmission 18 July 2001
13 December 2017 (online)
Magnesium deficiency is associated with a high frequency of cardiac arrhythmia, hypertension and sudden ischemic death. We investigated the in vivo effects of intravenous magnesium administration in a rat model of chemically induced (FeCl3) carotid thrombosis. The infusion of magnesium sulfate (MgSO4) before the topical application of FeCl3 prevented thrombus formation at concentrations of 0.3 M and 0.6 M, and delayed it even at 0.15 M. Similar results were obtained with MgCl2. The infusion of MgSO4 0.6 M seven minutes after FeCl3 application delayed but did not prevent thrombus formation. MgSO4 slightly reduced platelet aggregation ex vivo without affecting plasma clotting tests, but in vivo blood clotting time was markedly prolonged (tail transection method), thus indicating profoundly impaired coagulation. These data provide a rationale for the use of magnesium as an anti-thrombotic agent, but its pharmacological effect critically depends on the timing of administration.
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