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Thromb Haemost 2001; 85(06): 1060-1065
DOI: 10.1055/s-0037-1615964
Review Article
Schattauer GmbH

The Role of Factor XI in Thrombin Generation Induced by Low Concentrations of Tissue Factor

Irene M. L. W. Keularts
1   Department of Biochemistry, University of Maastricht, Maastricht, The Netherlands
,
Ariella Zivelin
2   Institute of Thrombosis and Hemostasis, Department of Hematology, Chaim Sheba Medical Center, Tel-Hashomer and Sackler School of Medicine, Tel-Aviv University, Israel
,
Uri Seligsohn
2   Institute of Thrombosis and Hemostasis, Department of Hematology, Chaim Sheba Medical Center, Tel-Hashomer and Sackler School of Medicine, Tel-Aviv University, Israel
,
H. Coenraad Hemker
1   Department of Biochemistry, University of Maastricht, Maastricht, The Netherlands
,
Suzette Béguin
1   Department of Biochemistry, University of Maastricht, Maastricht, The Netherlands
› Author Affiliations
Further Information

Publication History

Received 07 February 2000

Accepted after revision 06 February 2001

Publication Date:
12 December 2017 (online)

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Summary

Thrombin generation has been studied in the plasma of severely factor XI deficient patients under conditions in which contact activation did not play a role. In platelet-rich as well as platelet-poor plasma, thrombin generation was dependent upon the presence of factor XI at tissue factor concentrations of between 1 and 20 pg/ml i.e. ~ 0.01 to 0.20% of the concentration normally present in the thromboplastin time determination. The requirement for factor XI is low; significant thrombin generation was seen at 1% factor XI; at 10%, thrombin formation was nearly normalised. A suspension of normal platelets in severely factor XI deficient plasma did not increase thrombin generation. This implies that there is no significant factor XI activity carried by normal platelets, although the presence of factor XI and factor XI inhibitors in platelets cannot be ruled out.

Key words

Factor XI - thrombin generation - platelet procoagulant activity - tissue factor
 

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