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Thromb Haemost 1999; 82(S 01): 109-111
DOI: 10.1055/s-0037-1615565
Commentaries
Schattauer GmbH

Thrombolysis in Arterial Occlusion

Raymond Verhaeghe
1   From the Center for Molecular and Vascular Biology, University of Leuven, Belgium
› Author Affiliations
Further Information

Publication History

Publication Date:
14 December 2017 (online)

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Summary

Intra-arterial thrombolytic therapy has replaced systemic intravenous infusion of thrombolytic agents as a treatment modality for arterial occlusion in the limbs. Several catheter-guided techniques and various infusion methods and schemes have been developed. At present there is no scientific proof of definite superiority of any agent in terms of efficacy or safety but clinical practice favours the use of urokinase or alteplase. Studies which compared thrombolysis to surgical intervention suggest that thrombolytic therapy is an appropriate initial management in patients with acute occlusion of a native leg artery or a bypass graft. Underlying causative lesions are treated in a second step by endovascular or open surgical techniques. Severe bleeding is the most feared complication: the risk of hemorrhagic stroke is 1-2%.

Key words

Thrombolytic therapy - arterial occlusion - acute ischemia - vascular surgery
 

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