Thromb Haemost 1999; 82(S 01): 14-18
DOI: 10.1055/s-0037-1615546
Commentaries
Schattauer GmbH

Plasminogen Activator Inhibitor Type-1 (PAI-1) and its Role in Cardiovascular Disease

Thomas K. Nordt
1   Abteilung Kardiologie, Medizinische Klinik und Poliklinik, Universität Freiburg
,
Karlheinz Peter
1   Abteilung Kardiologie, Medizinische Klinik und Poliklinik, Universität Freiburg
,
Johannes Ruef
2   Abteilung Kardiologie, Medizinische Klinik und Poliklinik, Universität Heidelberg, Germany
,
Wolfgang Kübler
2   Abteilung Kardiologie, Medizinische Klinik und Poliklinik, Universität Heidelberg, Germany
,
Christoph Bode
1   Abteilung Kardiologie, Medizinische Klinik und Poliklinik, Universität Freiburg
› Author Affiliations
Further Information

Publication History

Publication Date:
14 December 2017 (online)

Summary

Cardiovascular disease is responsible for approximately 50% of total mortality in Europe, the USA and Japan (1). Established risk factors including smoking, hypercholesterolemia, and hypertension explain about half of the incidence of cardiovascular disease only (2). Reduced endogenous fibrinolytic activity secondary to increased plasma activity of plasminogen activator inhibitor type-1 (PAI-1) is now considered as a new cardiovascular risk factor. In this review, evidence is gathered for the notion that PAI-1 constitutes a predictor of cardiovascular disease and also contributes to the development of cardiovascular disease as a pathogenetic factor. The review will focus on experimental studies modulating PAI-1 activity and clinical studies addressing coronary heart disease, myocardial infarction, restenosis after coronary angioplasty, and graft occlusion after coronary artery bypass grafting.

 
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