Thromb Haemost 1998; 80(05): 763-766
DOI: 10.1055/s-0037-1615355
Review Article
Schattauer GmbH

Factor V Leiden and Prothrombin Gene G 20210 A Variant in Children with Ischemic Stroke

W. Zenz
1   From the Department of Pediatrics, University of Graz
2   From the Ludwig Boltzmann Institute for Pediatric Thrombosis and Hemostasis, Graz
,
Z. Bodó
1   From the Department of Pediatrics, University of Graz
,
Jutta Plotho
1   From the Department of Pediatrics, University of Graz
,
W. Streif
3   From the Department of Pediatrics, University of Innsbruck
,
Ch. Male
4   From the Department of Pediatrics, University of Vienna
,
G. Bernert
4   From the Department of Pediatrics, University of Vienna
,
L. Rauter
5   From the Department of Pediatrics, Landeskrankenhaus Leoben
,
G. Ebetsberger
6   From the Landeskinderklinik Linz
,
K. Kaltenbrunner
7   From the Department of Pediatrics, Landeskrankenhaus Villach
,
P. Kurnik
8   From the Department of Pediatrics, Landeskrankenhaus Klagenfurt
,
A. Lischka
9   From the Kinderklinik der Stadt Wien-Glanzing
,
F. Paky
10   From the Department of Pediatrics, Landeskrankenhaus Mödling
,
R. Ploier
11   From the Department of Pediatrics, Landeskrankenhaus Steyr
,
G. Höfler
12   From the Department of Pathology, University of Graz
,
Christine Mannhalter
13   From the Department of Laboratory Medicine, University of Vienna, Austria
,
W. Muntean
1   From the Department of Pediatrics, University of Graz
2   From the Ludwig Boltzmann Institute for Pediatric Thrombosis and Hemostasis, Graz
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Publikationsverlauf

Received 23. Februar 1998

Accepted after resubmission 24. Juli 1998

Publikationsdatum:
07. Dezember 2017 (online)

Summary

Objective: To investigate if the factor V Leiden mutation (F-V-LM) and/or the prothrombin gene G 20210 A variant (P-G20210A-V) are risk factors for acute stroke in Austrian children. Patients: 33 children with acute ischemic stroke documented by computer tomography and/or magnetic resonance imaging of the brain were enrolled in an open multicenter survey. Results: 6/33 children had F-V-LM (5 heterozygous, 1 homozygous). This represents 18% (95% CI: 6.7-39.9%) of our pediatric stroke population and thus exceeds the expected prevalence in the Austrian population of 4,6% (Fischer’s exact test, p = 0.01). F-V-LM was not found in 11 children with neonatal stroke but in 6/22 children with stroke after the neonatal period. 5/6 children with F-V-LM had an underlying disorder that is a risk factor for stroke in children. The P-G20210A-V was detected in 1/26 (3.85%; 95% CI: 0.1-21.4%) patients. Comparison of the prevalence of P-G20210A-V in our study with that in the general population of Austria of 1% revealed no statistical significance (Fischer’s exact test, p = 0.38). Conclusion: Our data suggest that the F-V-LM is a risk factor for acute stroke in Austrian children beyond the neonatal period. The P-G20210A-V apparently does not represent a risk factor for stroke in Austrian children.

 
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