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J Neurol Surg A Cent Eur Neurosurg 2019; 80(01): 053-057
DOI: 10.1055/s-0037-1615284
Case Report
Georg Thieme Verlag KG Stuttgart · New York

Immunohistochemical Analysis of Cerebral Intraparenchymal Choroid Plexus Tumor: Case Report

Masahito Katoh
1   Department of Neurosurgery, KKR Sapporo Medical Center, Sapporo, Japan
,
Yutaka Sawamura
2   Department of Neurosurgery, Sawamura Neurology and Neurosurgery Clinic, Sapporo, Japan
,
Shinya Tanaka
3   Laboratory of Molecular and Cellular Pathology, Hokkaido University Graduate School of Medicine, Sapporo, Japan
,
Takamitsu Fujimaki
4   Department of Neurosurgery, Saitama Medical University, Moroyama-machi, Saitama, Japan
,
Shigehisa Hirose
5   Department of Biological Science, Tokyo Kogyo Daigaku, Meguro-ku, Tokyo, Japan
,
Toshimitsu Aida
6   Department of Neurosurgery, Hokkaido Neurosurgical Memorial Hospital, Sapporo, Japan
› Author Affiliations
Further Information

Publication History

26 May 2017

23 October 2017

Publication Date:
04 July 2018 (online)

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Abstract

Background It is very rare for a choroid plexus tumor to occur intraparenchymally in the absence of a relation to the choroid plexus.

Clinical Presentation A case of cerebral intraparenchymal choroid plexus tumor in a 30-year-old woman presenting with left hemiparesis is described. Brain magnetic resonance imaging depicted a large cystic mass in the right frontal lobe. Tumor resection was performed by right frontal craniotomy. No connection with the choroid plexus was observed during the operation. Histologically, the tumor exhibited a glandular structure with a papillary pattern suggesting a neoplasm of epithelial origin. Immunohistochemical analyses revealed the tumor as an atypical choroid plexus papilloma.

Conclusion Immunohistochemical findings, especially regarding Kir7.1, are very important for the differential diagnosis of cerebral intraparenchymal choroid plexus tumors from metastatic tumors. The present case reveals that an atypical choroid plexus papilloma can occur intraparenchymally without an association with the choroid plexus. Intraparenchymal atypical choroid plexus papillomas may have previously been diagnosed incorrectly as metastatic adenocarcinomas of unknown origin.

Keywords

intraparenchymal - choroid plexus tumor - Kir7.1
 

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