Factor V Leiden Is not a Risk Factor for Arterial Vascular Disease in the Elderly: Results from the Cardiovascular Health Study

Mary Cushman; Frits R. Rosendaal; Bruce M. Psaty; E. Francis Cook; J. Valliere; Lewis H. Kuller; Russell P. Tracy

doi:10.1055/s-0037-1615092

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 1998; 79(05): 912-915
DOI: 10.1055/s-0037-1615092

Review Article

Schattauer GmbH

Factor V Leiden Is not a Risk Factor for Arterial Vascular Disease in the Elderly: Results from the Cardiovascular Health Study

Mary Cushman

¹From the University of Vermont, Departments of Medicine and Pathology, Burlington, VT, USA

,

Frits R. Rosendaal

²From the University Hospital, Departments of Clinical Epidemiology and Hematology, Leiden, The Netherlands

,

Bruce M. Psaty

³From the University of Washington, Departments of Medicine, Epidemiology, and Health Services, Seattle, WA, USA

,

E. Francis Cook

⁴From the Harvard University, Departments of Medicine and Preventive Health, Boston, MA, USA

,

J. Valliere

⁵From the University of Vermont, Department of Pathology, Burlington, VT, USA

,

Lewis H. Kuller

⁶From the University of Pittsburgh, Department of Epidemiology, Pittsburgh, PA, USA

,

Russell P. Tracy

⁵From the University of Vermont, Department of Pathology, Burlington, VT, USA

› Author Affiliations

Abstract

Summary

Coagulation factor V Leiden is a risk marker for venous thrombosis. For arterial thrombosis no large study to date has included population-based elderly patients. The Cardiovascular Health Study is a longitudinal study of 5,201 men and women over age 65. With 3.4-year follow-up, we studied 373 incident cases of myocardial infarction (MI), angina, stroke, or transient ischemic attack (TIA), and 482 controls. The odds ratios for each event with heterozygous factor V Leiden were: MI, 0.46 (95% CI 0.17 to 1.25); angina, 1.0 (95% CI 0.45 to 2.23); stroke, 0.77 (95% CI 0.35 to 1.70); TIA, 1.33 (95% CI 0.5 to 3.55); any outcome, 0.83 (95% CI 0.48 to 1.44). Adjustment for cardiovascular risk factors did not change relationships. In older adults factor V Leiden is not a risk factor for future arterial thrombosis.

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References

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