Thromb Haemost 1999; 82(06): 1776-1778
DOI: 10.1055/s-0037-1614919
Letters to the Editor
Schattauer GmbH

Management of Bleeding Using Recombinant Factor VIIa in a Patient Suffering from Bleeding Tendency due to a Lupus Anticoagulant-hypoprothrombinemia Syndrome

Mette Holm
1   From the University Department of Haematology, and Centre for Haemophilia and Thrombosis, Department of Clinical Immunology, University Hospital Aarhus, Denmark
,
Rinette Andreasen
2   Novo Nordisk A/S, Gentofte, Denmark
,
Jørgen Ingerslev
3   Centre for Haemophilia and Thrombosis, Department of Clinical Immunology, University Hospital Aarhus, Denmark
› Author Affiliations
Further Information

Publication History

Received 26 September 1997

Accepted after resubmission 01 July 1999

Publication Date:
10 December 2017 (online)

 

 
  • References

  • 1 Galli M, Barbui T. Antiprothrombin antibodies: detection and clinical significance in the antiphospholipid syndrome. Blood 1999; 93: 2149-57.
  • 2 Fleck RA, Rapaport S, Rao LVM. Anti-prothrombin and the lupus anticoagulant. Blood 1988; 72: 515-9.
  • 3 Diness V, Lund-Hansen T, Hedner U. Effect of recombinant human FVIIA on warfarin-induced bleeding in rats. Thromb Res 1990; 59: 921-9.
  • 4 Ley AB, Reader GG, Sorenson CW, Overman RS. Idiopathic hypoprothrombinemia associated with hemorrhagic diathesis and the effect of vitamin K. Blood 1955; 10: 691-706.
  • 5 Rapaport S, Ames SB, Duval BJ. A plasma coagulation defect in systemic lupus erythematosus arising from hypoprothrombinemia combined with antiprothrombinase activity. Blood 1960; 15: 212-27.
  • 6 Bajaj PS, Rapaport SI, Barclay S, Herbst KD. Aquired hypoprothrombinemia due to nonneutralizing antibodies to prothrombin: Mechanism and management. Blood 1985; 65: 1538-43.
  • 7 Williams S, Linardic C, Wilson O, Comp F, Gralnick HR. Acquired hypoprothrombinemia: effets of danazol treatment. Am J Hematol 1996; 53: 272-6.
  • 8 Pernod G, Arvieux J, Carpentier PH, Mossuz P, Bosson JL, Polack B. Successful treatment of lupus anticoagulant-hypoprothrombinemia syndrome using intravenous immunoglobulin. Thomb Haemost 1997; 78: 969-70.