Thromb Haemost 1999; 82(05): 1555-1556
DOI: 10.1055/s-0037-1614872
Letters to the Editor
Schattauer GmbH

High Frequency of Factor V Leiden Mutation and Prothrombin 20210A Variant in Romanies of Eastern Hungary

I. Balogh
1   From the Department of Clinical Biochemistry and Molecular Pathology, University Medical School, Debrecen, Hungary
,
R. Póka
2   Department of Obstetrics and Gynecology, University Medical School, Debrecen, Hungary
,
G. Losonczy
1   From the Department of Clinical Biochemistry and Molecular Pathology, University Medical School, Debrecen, Hungary
,
L. Muszbek
1   From the Department of Clinical Biochemistry and Molecular Pathology, University Medical School, Debrecen, Hungary
› Author Affiliations
Further Information

Publication History

Received 25 January 1999

Accepted after revision 15 March 1999

Publication Date:
09 December 2017 (online)

 

 
  • References

  • 1 Dahlbäck B, Carlsson M, Svensson PJ. Familial thrombophilia due to a previously unrecognized mechanism characterized by poor anticoagulant response to activated protein C: Prediction of a cofactor to activated protein C. Proc Natl Acad Sci USA 1993; 90: 1004-8.
  • 2 Bertina RM, Koeleman BPC, Koster T, Rosendaal FR, Driven RJ, De Ronde H, Van Der Velden PA, Reitsma PH. Mutation in blood coagulation factor V associated with resistance to activated protein C. Nature 1994; 369: 64-7.
  • 3 Poort SR, Rosendaal FR, Reitsma PH, Bertina RM. A common genetic variation in the 3’-untranslated region of the prothrombin gene is associated with elevated plasma prothrombin levels and an increase in venous thrombosis. Blood 1996; 88: 3698-703.
  • 4 Rosendaal FR, Doggen CJM, Zivelin A, Arruda VR, Aiach M, Siscovick DS, Hillarp A, Watzke HH, Bernardi F, Cummins AM, Preston FE, Reitsma PH. Geographic distribution of the 20210 G to A prothrombin variant. Thromb Haemost 1998; 79: 706-8.
  • 5 Koeleman BPC, Reitsma PH, Allaart CF, Bertina RM. Activated protein C resistance as an additional risk factor for thrombosis in protein C-deficient families. Blood 1994; 84: 1031-5.
  • 6 Assal S, Susanszky E, Czeizel A. High consanguinity rate in Hungarian gipsy communities. Acta Paediatr Hung 1991; 31: 299-304.
  • 7 Rees DC, Cox M, Clegg JB. World distribution of factor V Leiden. Lancet 1995; 346: 1133-4.
  • 8 Garewal G, Das R, Trehan U. Factor V Leiden: Prevalence in the indigenous population and cases of thrombosis in North India. Brit J. Haematol 1997; 97: 940.
  • 9 Hermann FH, Koesling M, Schröder W, Altman R, Jimenez Bouilla R, Lopaciuk S, Perez-Requejo JL, Singh JR. Prevalence of factor V Leiden mutation in various populations. Genet Epidemiol 1997; 14: 403-11.