Elevated Levels of sE-selectin in Post-menopausal Females Are Decreased by Hormone Replacement Therapy to Levels Observed in Pre-menopausal Females

Gwen Kennedy; Margaret McLaren; Jill J. F. Belch; Mary Seed

doi:10.1055/s-0037-1614850

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 1999; 82(05): 1433-1436
DOI: 10.1055/s-0037-1614850

Rapid Communications

Schattauer GmbH

Elevated Levels of sE-selectin in Post-menopausal Females Are Decreased by Hormone Replacement Therapy to Levels Observed in Pre-menopausal Females

Gwen Kennedy

²National Heart and Lung Institute, Imperial College School of Medicine, Charing Cross Hospital, London, UK

,

Margaret McLaren

²National Heart and Lung Institute, Imperial College School of Medicine, Charing Cross Hospital, London, UK

,

Jill J. F. Belch

²National Heart and Lung Institute, Imperial College School of Medicine, Charing Cross Hospital, London, UK

,

Mary Seed

¹From the Section of Vascular Medicine and Biology, University Department of Medicine, Ninewells Hospital & Medical School, Dundee, and the National Heart and Lung Institute, Imperial College School of Medicine, Charing Cross Hospital, London, UK

› Author Affiliations

Abstract

Summary

Observational epidemological studies have shown that mortality from coronary heart disease is reduced in post-menopausal women by hormone replacement therapy (HRT). The aim of this study was to measure sE-selectin levels in post-menopausal females before and after HRT and to compare these with pre-menopausal females and aged matched males. Post-menopausal females (n = 70) were given HRT or no treatment to act as a control group. sE-selectin levels were significantly lower in the pre-menopausal (n = 36) when compared with the post-menopausal females (n = 70) (p = 0.027), whereas no difference between two age matched male groups was found (n = 40). Oral and transdermal HRT significantly decreased sE-selectin levels (p <0.0001 and p = 0.0005 respectively) with no change in the control group. The reduction in the levels of this marker of endothelial activation after HRT, may reflect a decrease in leucocyte/endothelial interaction which may reduce atherosclerotic risk in post-menopausal females.

Keywords

E-selectin - atherosclerosis - hormone replacement therapy - endothelium - leucocyte

Full Text

References

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