Inversion of Intron 22 of the Factor VIII Gene in a Girl with Severe Hemophilia A and Turner’s Syndrome

Thromb Haemost 1999; 82(04): 1379
DOI: 10.1055/s-0037-1614406

Letters to the Editor

Schattauer GmbH

Ampaiwan Chuansumrit

⁵From the Department of Pediatics, Royal Hallamshire Hospital, Sheffield, U.K.

,

Werasak Sasanakul

¹Research Center, Royal Hallamshire Hospital, Sheffield, U.K.

,

Anne Goodeve

²Section of Molecular Genetics and Haematology, Department of Medicine and Pharmacology, Royal Hallamshire Hospital, Sheffield, U.K.

,

Taneenat Treratvirapong

³Taksin Hospital, Bangkok, Thailand, Royal Hallamshire Hospital, Sheffield, U.K.

,

Rachanee Parinayok

⁴Pathology, Faculty of Medicine, Ramathibodi Hospital, Royal Hallamshire Hospital, Sheffield, U.K.

,

Pakaimas Pintadit

¹Research Center, Royal Hallamshire Hospital, Sheffield, U.K.

,

Phongjan Hathirat

⁵From the Department of Pediatics, Royal Hallamshire Hospital, Sheffield, U.K.

References
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2 Pietu G, Thomas-Maison N, Sie P, Larrieu M, Meyer D. Hemophilia A in a female: study of a family using intragenic and extragenic restriction site polymorphisms. Thromb Haemost 1988; 60: 102-6.
3 Mannucci PM, Coppola R, Lombardi R, Papa M, De Baisi R. Direct proof of extreme lyonization as a cause of low factor VIII levels in female. Thromb Haemost 1978; 39: 544-5.
4 Gilchrist GS, Hammond D, Melnyk J. Hemphilia A in a phenotypically normal female with XX/XO mosaicism. N Engl J Med 1965; 273: 1402-6.
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6 Antonarakis SS. A consortium of 65 International Authors. Factor VIII gene inversion in severe haemopohilia A-results of an international consortium study. Blood 1995; 86: 2206-12.