A Possible Solution to the Paradox of the “Lupus Anticoagulant”: Antiphospholipid Antibodies Accelerate Thrombin Generation by Inhibiting Annexin-V

Thromb Haemost 1999; 82(04): 1376-1377
DOI: 10.1055/s-0037-1614404

Letters to the Editor

Schattauer GmbH

Authors

Jacob H. Rand

¹From the Department of Medicine, Divisions of Hematology and Thrombosis, New York, NY, USA
Xiao-Xuan Wu

¹From the Department of Medicine, Divisions of Hematology and Thrombosis, New York, NY, USA
Peter Giesen

²Mount Sinai School of Medicine, New York, NY, USA

References
1 Hughes GR. Hughes’ syndrome: the antiphospholipid syndrome. A historical view. Lupus 1998; 7 (Suppl. 02) S1-S4.
2 Rand JH. The antiphospholipid antibody syndrome: new insights on thrombogenic mechanisms. Am J Med Sci 1998; 316: 142-51.
3 Rand JH, Wu XX, Andree HAM, Lockwood CJ, Guller S, Scher J, Harpel PC. Pregnancy loss in the antiphospholipid-antibody syndrome – a possible thrombogenic mechanism. N Engl J Med 1997; 337: 154-60.
4 Rand JH, Wu XX, Andree HAM, Alexander Ross JB, Rosinova E, Gascon-Lema MG, Calandri C, Harpel PC. Antiphospholipid antibodies accelerate plasma coagulation by inhibiting annexin-V binding to phospholipids: a »lupus procoagulant« phenomenon. Blood 1998; 92: 1652-60.
5 Andree HAM, Stuart MC, Hermens WT, Reutelingsperger CP, Hemker HC, Frederik PM, Willems GM. Clustering of lipid-bound annexin V may explain its anticoagulant effect. J Biol Chem 1992; 267: 17907-12.