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Short-term Prognostic Value of Lipid Measurements in Patients with Angina pectorisThis work was carried out within the framework of the “European Concerted Action on Thrombosis and Disabilities (ECAT)” of the Commission of the European Communities.
07 March 2000
Accepted after resubmission 10 July 2000
13 December 2017 (online)
We studied the role of various markers of lipid metabolism, hemostasis and inflammation in a two year follow-up of 3000 patients with angina pectoris, during which time 106 patients experienced myocardial infarction or sudden coronary death. Low levels of high density lipoprotein (HDL) cholesterol and of apolipoprotein (apo) A-I were most strongly associated with increased coronary risk. The relative risk per standard deviation increase was 0.68 for HDL cholesterol (95% confidence interval 0.55 to 0.84) and 0.66 for apoA-I (0.54 to 0.81). These associations were independent of other coronary risk factors, other lipid measurements, hemostatic factors, and C-reactive protein (CRP). The associations of total and LDL cholesterol, triglycerides, apoB, and lipoprotein(a) with coronary events were not independent of HDL cholesterol or hemostatic factors. We conclude that HDL cholesterol or apoA-I, hemostatic risk factors, and CRP are important prognostic markers of coronary events in secondary prevention.
KeywordsHDL cholesterol - apolipoprotein A-I - hemostatic factors - C-reactive protein - acute phase markers
* Participants listed in the appendix, pls see pp. 959–60.
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