Thromb Haemost 2000; 84(06): 955-960
DOI: 10.1055/s-0037-1614155
Review Article
Schattauer GmbH

Short-term Prognostic Value of Lipid Measurements in Patients with Angina pectoris

Ignasi Bolibar
1   Servei d’Epidemiología Clinica y Salud Pública, Barcelona, Spain
,
Arnold von Eckardstein
2   Institut für Klinische Chemie und Laboratoriumsmedizin and Institut für Arterioskleroseforschung, Münster, Germany
,
Gerd Assmann
2   Institut für Klinische Chemie und Laboratoriumsmedizin and Institut für Arterioskleroseforschung, Münster, Germany
,
Simon Thompson
3   Department of Medical Statistics and Evaluation, Imperial College School of Medicine, Hammersmith Hospital, London, UK
,
The ECAT Angina Pectoris Study Group › Author Affiliations
This work was carried out within the framework of the “European Concerted Action on Thrombosis and Disabilities (ECAT)” of the Commission of the European Communities.
Further Information

Publication History

Received 07 March 2000

Accepted after resubmission 10 July 2000

Publication Date:
13 December 2017 (online)

Summary

We studied the role of various markers of lipid metabolism, hemostasis and inflammation in a two year follow-up of 3000 patients with angina pectoris, during which time 106 patients experienced myocardial infarction or sudden coronary death. Low levels of high density lipoprotein (HDL) cholesterol and of apolipoprotein (apo) A-I were most strongly associated with increased coronary risk. The relative risk per standard deviation increase was 0.68 for HDL cholesterol (95% confidence interval 0.55 to 0.84) and 0.66 for apoA-I (0.54 to 0.81). These associations were independent of other coronary risk factors, other lipid measurements, hemostatic factors, and C-reactive protein (CRP). The associations of total and LDL cholesterol, triglycerides, apoB, and lipoprotein(a) with coronary events were not independent of HDL cholesterol or hemostatic factors. We conclude that HDL cholesterol or apoA-I, hemostatic risk factors, and CRP are important prognostic markers of coronary events in secondary prevention.

* Participants listed in the appendix, pls see pp. 959–60.