Is there a Role for Genetic Polymorphism of C677T Methylenetetrahydrofolate Reductase (MTHFR) in Buerger’s Disease?

Thromb Haemost 2000; 84(04): 736-737
DOI: 10.1055/s-0037-1614104

Letters to the Editor

Schattauer GmbH

T. Kawasaki

¹From the division of Vascular Surgery, Department of Surgery, Osaka University Hospital, Japan

,

H. Fujimura

¹From the division of Vascular Surgery, Department of Surgery, Osaka University Hospital, Japan

,

E. Kakinoki

²Kozu Hospital, Japan

,

A. Uemichi

²Kozu Hospital, Japan

,

T. Miyata

³National Cardiovascular Center Research Institute, Osaka, Japan

References
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2 Frosst P, Blom HJ, Milos R. et al. A candidate genetic risk factor for vascular disease: a common mutation in methylenetetrahydrofolate reductase. Nat Genet 1995; 10: 111-3.
3 Piyathilake CJ, Macaluso M, Hine RJ, Richards EW, Krumdieck CL. Local and systemic effects of cigarette smoking on folate and vitamine B12. Am J Clin Nutr 1994; 60: 559-66.
4 Shionoya S. Buerger’s disease: diagnosis and management. Cardiovasc Surg 1993; 01: 207-14.
5 Fujimura H, Kawasaki T, Sakata T, Sakata T, Ariyoshi H, Kato H, Monden M, Miyata T. Common C677T polymorphism in the methylenetetrahydrofolate reductase gene increases the risk for deep vein thrombosis in patients with predisposition to thrombophilia. Thrombos Res 2000; 98: 1-8.