Coagulation Factor II Activity Determination Is Not Useful as a Screening Tool for the G20210A Prothrombin Gene Allele

Thromb Haemost 2000; 84(01): 141-142
DOI: 10.1055/s-0037-1613985

Letters to the Editor

Schattauer GmbH

M. Gruenewald

¹From the Division of Haemostaseology, Department of Haematology, University of Ulm, Germany

,

A. Germowitz

¹From the Division of Haemostaseology, Department of Haematology, University of Ulm, Germany

,

H. Beneke

¹From the Division of Haemostaseology, Department of Haematology, University of Ulm, Germany

,

C. Guethner

¹From the Division of Haemostaseology, Department of Haematology, University of Ulm, Germany

,

M. Griesshammer

¹From the Division of Haemostaseology, Department of Haematology, University of Ulm, Germany

References
1 Poort SR, Rosendaal FR, Reitsma PH, Bertina RM. A common genetic variation in the 3’-untranslated region of the prothrombin gene is associated with elevated plasma prothrombin levels and an increase in venous thrombosis. Blood 1996; 88: 3698-703.
2 Lindmarker P, Schulman S, Sten-Linder M, Wiman B, Egberg N, Johnsson H. the DURAC Trial Study Group. The risk of recurrent venous thromboembolism in carriers and non-carriers of the G1691A allele in the coagulation factor V gene and the G20210A allele in the prothrombin gene. Thromb Haemost 1999; 81: 684-9.
3 Hillarp A, Zöller B, Svensson PJ, Dahlbäck B. The 20210A allele of the prothrombin gene is a common risk factor among swedish outpatients with a verfied deep venous thrombosis. Thromb Haemost 1997; 78: 990-2.
4 Makris M, Preston FE, Beauchamp N J, Cooper PC, Daly ME, Hampton KK, Bayliss P, Peake IR, Miller GJ. Co-inheritance of the 20210A allele of the prothrombin gene increases the risk of thrombosis in subjects with familial thrombophilia. Thromb Haemost 1997; 78: 1426-9.
5 Arruda VR, Annichino-Bizzacchi JM, Goncalves MS, Costa FF. Prevalence of the prothrombin gene variant (nt20210A) in venous thrombosis and arterial disease. Thromb Haemost 1997; 78: 1430-3.
6 Cumming AM, Keeney S, Salden A, Bhavnani M, Shwe KH, Hay CRM. The prothrombin gene G20210A variant: prevalence in a U. K. anticoagulation clinic population. Br J Haematol 1997; 98: 353-5.