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Thromb Haemost 2000; 84(01): 118-123
DOI: 10.1055/s-0037-1613978
Commentary
Schattauer GmbH

Effect of Strenuous Arm Exercise on Oxidized-LDL-Potentiated Platelet Activation in Individuals with Spinal Cord Injury

Jong-Shyan Wang
3   From the Department of Physical Therapy, Chang Gung University, Taoyuan, Taiwan
,
Chih Fang Yang
1   Department of Physical Medicine and Rehabilitation, Chang Gung Memorial Hospital, Taoyuan, Taiwan
,
May-Kuen Wong
1   Department of Physical Medicine and Rehabilitation, Chang Gung Memorial Hospital, Taoyuan, Taiwan
,
Shu-Er Chow
2   Department of Physiology, Chang Gung University, Taoyuan, Taiwan
,
Jan-Kan Chen
2   Department of Physiology, Chang Gung University, Taoyuan, Taiwan
› Author AffiliationsThe study was support under the National Science Council Grant NSC 90-2320-B-182-006. The authors would like to thank the volunteers for their enthusiastic participation in this study.
Further Information

Publication History

Received 03 January 2000

Accepted after revision 21 February 2000

Publication Date:
10 December 2017 (online)

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Summary

This study investigates how strenuous arm exercise affects oxidizedlow density lipoprotein (Ox-LDL) mediated-platelet activation in patients with SCI. Ten patients with SCI and ten age- and sex-matched healthy subjects exercised strenuously using an arm crank ergometer. The following measurements were taken both when the subjects were at rest, and immediately after exercise: plasma lipid profile, Ox-LDL mediated platelet aggregability and [Ca2+]i, urinary 11-dehydro-thromboxane B2 (11-dehydro-TXB2) and 8-iso-prostaglandin F2α. (8-iso-PG F2α.) contents, and plasma NO metabolite (nitrite plus nitrate) level. Based on these measurements, the major findings of this study can be summarized as follows: 1) the SCI group had higher urinary 8-iso- PGF2α. and 11-dehydro-TXB2 contents, but a lower plasma nitrite plus nitrate level than the control group; 2) at rest, the SCI group had a higher platelet aggregability and [Ca2+]i, and Ox-LDL-potentiated platelet activation than the control group; 3) Ox-LDL-potentiated platelet aggregation was enhanced by strenuous arm exercise in both groups, but the effect of exercise was more pronounced in the SCI group than in the control group; 4) treating the platelet with L-arginine inhibited Ox-LDL-potentiated platelet activation in both groups. The study concludes that individuals with SCI had more extensive resting and exercise-enhanced Ox-LDL-potentiated platelet activation and greater amounts of preformed lipid peroxides than those without SCI. Therefore, supplementation therapy with antioxidants may be needed for patients with SCI, especially in a strenuous arm exercise period.

Key words

SCI - exercise - platelet - nitric oxide - Ox-LDL
 

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