Download PDF
Thromb Haemost 2000; 83(03): 509-510
DOI: 10.1055/s-0037-1613845
Letters to the Editor
Schattauer GmbH

Factor V Leiden and Prothrombin G 20210A Variant Are Risk Factors for Venous Thromboembolism in the Argentinean Population

Y. Adamczuk
1   From the Institute of Cardiology and Cardiovascular Surgery, Favaloro University, Favaloro Foundation, Buenos Aires, Argentina
,
M. L. Iglesias Varela
1   From the Institute of Cardiology and Cardiovascular Surgery, Favaloro University, Favaloro Foundation, Buenos Aires, Argentina
,
R. Forastiero
1   From the Institute of Cardiology and Cardiovascular Surgery, Favaloro University, Favaloro Foundation, Buenos Aires, Argentina
,
M. Martinuzzo
1   From the Institute of Cardiology and Cardiovascular Surgery, Favaloro University, Favaloro Foundation, Buenos Aires, Argentina
,
G. Cerrato
1   From the Institute of Cardiology and Cardiovascular Surgery, Favaloro University, Favaloro Foundation, Buenos Aires, Argentina
,
G. Pombo
1   From the Institute of Cardiology and Cardiovascular Surgery, Favaloro University, Favaloro Foundation, Buenos Aires, Argentina
,
L. O. Carreras
1   From the Institute of Cardiology and Cardiovascular Surgery, Favaloro University, Favaloro Foundation, Buenos Aires, Argentina
› Author Affiliations
Further Information

Publication History

Received 20 October 1999

Accepted 05 November 1999

Publication Date:
14 December 2017 (online)

    Permissions and Reprints

 

 

  • References

  • 1 Bertina RM, Koeleman RPC, Koster T, Rosendaal FR, Dirven RJ, de Ronde H, van der Velden PA, Reitsma PH. Mutation in blood coagulation factor V associated with resistance to activated protein C. Nature 1994; 369: 64-7.
    CrossrefPubMedGoogle Scholar
  • 2 Poort SR, Rosendaal FR, Reitsma PH, Bertina RM. A common genetic variation in the 3’-untranslated region of the prothrombin gene is associated with elevated plasma prothrombin levels and an increase in venous thrombosis. Blood 1996; 88: 3698-703.
    PubMedGoogle Scholar
  • 3 Rees DC, Cox M, Clegg JB. World distribution of factor V Leiden. Lancet 1995; 346: 1133-4.
    CrossrefPubMedGoogle Scholar
  • 4 Rosendaal FR, Doggen CJM, Zivelin A, Arruda VR, Aiach M, Siscovick DS, Hillarp A, Watzke HH, Bernardi F, Cumming AM, Preston FE, Reitsma PH. Geographic distribution of the 20210 G to A prothrombin variant. Thromb Haemost 1998; 79: 706-8.
    Article in Thieme ConnectPubMedGoogle Scholar
  • 5 Zöller B, Svensson PJ, He X, Dahlbäck B. Identification of the same factor V gene mutation in 47 out of 50 thrombosis-prone families with inherited resistance to activated protein C. J Clin Invest 1994; 94: 2521-4.
    CrossrefPubMedGoogle Scholar
  • 6 Hepner M, Roldan A, Pieroni G, Frontroth JP, Serviddio RM, Feliú ATorres, Sciuccati G, Bonduel M. Factor V Leiden mutation in the Argentinean population. Thromb Haemost 1999; 81: 989.
    Article in Thieme ConnectPubMedGoogle Scholar
  • 7 Poort SR, Bertina RM, Vos HL. Rapid detection of the prothrombin 20210A variation by allele specific PCR. Thromb Haemost 1997; 78: 1157-63.
    Article in Thieme ConnectPubMedGoogle Scholar
  • 8 Rodeghiero F, Tosetto A. Activated protein C resistance and factor V Leiden mutation are independent risk factors for venous thromboembolism. Ann Intern Med 1999; 130: 643-50.
    CrossrefPubMedGoogle Scholar
  • 9 Souto JC, Coll I, Llobet D, del Río E, Oliver A, Mateo J, Borrell M, Fontcuberta J. The prothrombin 20210A allele is the most prevalent genetic risk factor for venous thromboembolism in the Spanish population. Thromb Haemost 1998; 80: 366-9.
    Article in Thieme ConnectPubMedGoogle Scholar