The Factor V R2 Allele: Risk of Venous Thromboembolism, Factor V Levels and Resistance to Activated Protein C

Roger Luddington; Andrew Jackson; Sabapathy Pannerselvam; Karen Brown; Trevor Baglin

doi:10.1055/s-0037-1613786

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 2000; 83(02): 204-208
DOI: 10.1055/s-0037-1613786

Rapid Communication

Schattauer GmbH

The Factor V R2 Allele: Risk of Venous Thromboembolism, Factor V Levels and Resistance to Activated Protein C

Roger Luddington

¹From the Department of Haematology, Addenbrooke’s NHS Trust, Cambridge, United Kingdom

,

Andrew Jackson

¹From the Department of Haematology, Addenbrooke’s NHS Trust, Cambridge, United Kingdom

,

Sabapathy Pannerselvam

¹From the Department of Haematology, Addenbrooke’s NHS Trust, Cambridge, United Kingdom

,

Karen Brown

¹From the Department of Haematology, Addenbrooke’s NHS Trust, Cambridge, United Kingdom

,

Trevor Baglin

¹From the Department of Haematology, Addenbrooke’s NHS Trust, Cambridge, United Kingdom

› Author Affiliations

Abstract

Summary

Case-control studies have yielded conflicting results regarding the relative risk of venous thromboembolism associated with the factor V R2 allele. We calculated odds ratios in 581 patients and 469 agematched controls. The odds ratio for the R2 allele in patients relative to controls was 1.21 (95% CI 0.84 to 1.74). These results do not support the hypothesis that the R2 allele is a risk factor for venous thromboembolism. There was no relationship between factor V levels and R2 carrier status. Normalised APC sensitivity ratios were not lower in carriers of the R2 allele. In an in vitro model progressive APC resistance was observed with factor V levels of 60% and less but ratios less than 2.4 (equivalent to a normalised ratio of 0.73) did not occur until factor V levels were less than 20%. The relationship between APC resistance and factor V level was not observed in a factor VIII-independent model.

Keywords

Factor V - HR2 haplotype - R2 allele - APC resistance - thrombosis

Full Text

References

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