Rise of circulating thrombopoietin following cardiothoracic surgery is potentiated in patients with coronary atherosclerosis: correlation with a preceding increase in levels of interleukin-6

James M. Cotton; Ying Hong; Emma Hawe; Anthony Mathur; Steve E. Humphries; Angie S. Brown; John F. Martin; Jorge D. Erusalimsky

doi:10.1055/s-0037-1613385

Thrombosis and Haemostasis, Inhaltsverzeichnis

Thromb Haemost 2003; 89(03): 538-543
DOI: 10.1055/s-0037-1613385

Vascular Development and Vessel Remodeling

Schattauer GmbH

Rise of circulating thrombopoietin following cardiothoracic surgery is potentiated in patients with coronary atherosclerosis: correlation with a preceding increase in levels of interleukin-6

James M. Cotton

¹Department of Cardiology, King’s College, GKT School of Medicine and Dentistry, London, UK and the Centres for

,

Ying Hong

²Cardiovascular Biology and Medicine, British Heart Foundation Laboratories, Department of Medicine, University College London, London, UK

,

Emma Hawe

³Cardiovascular Genetics, British Heart Foundation Laboratories, Department of Medicine, University College London, London, UK

,

Anthony Mathur

²Cardiovascular Biology and Medicine, British Heart Foundation Laboratories, Department of Medicine, University College London, London, UK

,

Steve E. Humphries

³Cardiovascular Genetics, British Heart Foundation Laboratories, Department of Medicine, University College London, London, UK

,

Angie S. Brown

¹Department of Cardiology, King’s College, GKT School of Medicine and Dentistry, London, UK and the Centres for

,

John F. Martin

²Cardiovascular Biology and Medicine, British Heart Foundation Laboratories, Department of Medicine, University College London, London, UK

,

Jorge D. Erusalimsky

²Cardiovascular Biology and Medicine, British Heart Foundation Laboratories, Department of Medicine, University College London, London, UK

› Institutsangaben

Abstract

Summary

Thrombopoietin (TPO) is the major regulator of platelet production. Plasma levels of TPO are thought to be regulated by its binding to platelets and megakaryocytes. Here we have used a model of cardiac surgery with cardiopulmonary bypass (CBP) to test the possibility that changes in TPO levels are influenced by the presence of coronary artery disease (CAD) and by changes in interleukin-6 (IL-6). After surgery patients with CAD (n = 22) or with normal coronary arteries (n = 11) showed a significant thrombocytopaenia followed by a reactive thrombocytosis. The platelet recovery was preceded by a significant rise in TPO (from 62.6 ± 9.4 pg/ml at baseline to 129.2 ± 19 pg/ml at 60 h, P <0.001), which in turn was preceded by, and was positively correlated with, a marked increase in circulating IL-6 (from 1.5 ± 0.3 pg/ml at baseline to 269.3 ± 30.6 pg/ml at 3-12 h, P <0.001). The rise of both IL-6 and TPO was significantly larger in patients with CAD. No correlation was found between the post-operative drop in platelet mass and changes in either the TPO or IL-6 levels. These findings suggest that in man circulating TPO levels, besides being controlled by changes in platelet mass, are influenced by inflammatory processes, including the presence of coronary atherosclerosis.

Keywords

Atherosclerosis - thrombopoietin - interleukin-6 - platelets - cardiovascular surgery

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Referenzen

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