Z Gastroenterol 2018; 56(01): E2-E89
DOI: 10.1055/s-0037-1612831
Poster Visit Session IV Tumors, Liver Surgery and Transplantation – Saturday, January 27, 2018, 8:30am – 9:15am, Foyer area West Wing
Georg Thieme Verlag KG Stuttgart · New York

Establishing a Porcine Model of Small for Size Syndrome following Liver Resection

Authors

  • E Khajeh

    1   University of Heidelberg, General, Visceral, and Transplantation Surgery, Heidelberg

  • M Golriz

    1   University of Heidelberg, General, Visceral, and Transplantation Surgery, Heidelberg

  • M Ashrafi

    1   University of Heidelberg, General, Visceral, and Transplantation Surgery, Heidelberg

  • A Majlesara

    1   University of Heidelberg, General, Visceral, and Transplantation Surgery, Heidelberg

  • C Flechtenmacher

    2   University of Heidelberg, General Pathology, Heidelberg

  • A Mehrabi

    1   University of Heidelberg, General, Visceral, and Transplantation Surgery, Heidelberg
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Publikationsverlauf

Publikationsdatum:
03. Januar 2018 (online)

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Background:

small for size syndrome (SFSS) is responsible for a high proportion of mortalities and morbidities following extended liver resection. The aim of this study was to establish a porcine model of SFSS.

Methods:

Twenty-four Landrace pigs underwent liver resection with a remnant liver volume of 50% (group A, n = 8), 25% (group B, n = 8), and 15% (group C, n = 8). After resection, the animals were followed up for 8 days and clinical, laboratory, and histopathological outcomes were evaluated.

Results:

The survival rate was significantly lower in group C compared with the other groups (p < 0.001). The international normalized ratio, bilirubin, aspartate transaminase, alanine transaminase, and alkaline phosphatase levels increased shortly after surgery in group B and C, but no change was observed in group A (p < 0.05 for all analyses). The histopathological findings in group A were mainly mild mitoses, in group B severe mitoses and hepatocyte ballooning, moderate congestion and hemorrhage, along with mild necrosis, and in group C extended tissue damage with severe necrosis, hemorrhage, and congestion.

Conclusions:

Combination of clinical, laboratory, and histopathological evaluations are needed to confirm the diagnosis of SFSS. 75% liver resection in porcine model results in SFSS. 85% liver resection causes irreversible liver failure.