CC BY-ND-NC 4.0 · Synthesis 2019; 51(01): 146-160
DOI: 10.1055/s-0037-1610396
short review
Copyright with the author

Twofold Ferrocene C–H Lithiations For One-Step Difunctionalizations

Univ Rennes, CNRS, ISCR (Institut des Sciences Chimiques de Rennes) - UMR 6226, 35000 Rennes, France   Email: william.erb@univ-rennes1.fr   Email: florence.mongin@univ-rennes1.fr
,
Univ Rennes, CNRS, ISCR (Institut des Sciences Chimiques de Rennes) - UMR 6226, 35000 Rennes, France   Email: william.erb@univ-rennes1.fr   Email: florence.mongin@univ-rennes1.fr
› Author Affiliations
Université de Rennes 1.
Further Information

Publication History

Received: 29 October 2018

Accepted: 05 November 2018

Publication Date:
05 December 2018 (eFirst)

  

Abstract

For some aromatics, a twofold C–H deprotolithiation can be achieved, allowing these compounds to be subsequently difunctionalized in one step. This short review brings together examples in which ferrocenes are converted in this way.

1 Introduction

2 Bare Ferrocene

3 Ferrocenes Substituted by Alkyl or Silyl Groups

4 Ferrocenes Substituted by Aminoalkyls

5 Ferrocenes Substituted by Halogens or Oxygen-Based Groups

6 Ferrocenes Substituted by Alkoxyalkyls or Acetals

7 Ferrocenes Substituted by Sulfoxides

8 Ferrocenes Substituted by Oxazolines

9 Ferrocenes Substituted by Carboxamides

10 Conclusion

 
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