Open Access
CC BY ND NC 4.0 · SynOpen 2018; 02(04): 0263-0267
DOI: 10.1055/s-0037-1610370
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Efficient S-Acylation of Thiourea

David J. Jones
a   School of Chemistry, University College Cork, Cork, Ireland   eMail: tim.osullivan@ucc.ie
b   Analytical and Biological Chemistry Research Facility, University College Cork, Cork, Ireland
e   Synthesis and Solid-State Pharmaceutical Centre, University College Cork, Cork, Ireland
,
a   School of Chemistry, University College Cork, Cork, Ireland   eMail: tim.osullivan@ucc.ie
b   Analytical and Biological Chemistry Research Facility, University College Cork, Cork, Ireland
,
Eileen M. O’Leary
c   Department of Physical Sciences, Cork Institute of Technology, Cork, Ireland
,
a   School of Chemistry, University College Cork, Cork, Ireland   eMail: tim.osullivan@ucc.ie
b   Analytical and Biological Chemistry Research Facility, University College Cork, Cork, Ireland
e   Synthesis and Solid-State Pharmaceutical Centre, University College Cork, Cork, Ireland
,
a   School of Chemistry, University College Cork, Cork, Ireland   eMail: tim.osullivan@ucc.ie
b   Analytical and Biological Chemistry Research Facility, University College Cork, Cork, Ireland
d   School of Pharmacy, University College Cork, Cork, Ireland
› Institutsangaben

This research received financial support from Science Foundation Ireland­ under Grant Numbers 12/RC/2275, 05/PICA/B802/EC07, 14/US/E2915 (UBRK) and the UCC Strategic Research Fund (UBRK and DJJ).
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Publikationsverlauf

Received: 16. August 2018

Accepted after revision: 12. September 2018

Publikationsdatum:
17. Oktober 2018 (online)


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Abstract

Efficient S-acylation of thiourea using a variety of acid chlorides is reported. Structurally diverse aryl and alkyl substrates are compatible with this methodology. Confirmation that acylation occurs exclusively­ on the sulfur atom of thiourea is provided by single-crystal X-ray crystallographic analysis.

Supporting Information