Synthesis
DOI: 10.1055/s-0037-1610274
paper
© Georg Thieme Verlag Stuttgart · New York

A General Protocol for the Synthesis of H-α-Hydroxyphosphinates

Jade Dussart
,
Université Paris 13, Sorbonne Paris Cité, Laboratoire CSPBAT, CNRS UMR 7244, 93017 Bobigny Cedex, France   eMail: julia.deschamp@univ-paris13.fr   eMail: marc.lecouvey@univ-paris13.fr
,
Maelle Monteil
,
Olivier Gager
,
Evelyne Migianu-Griffoni
,
Marc Lecouvey*
Université Paris 13, Sorbonne Paris Cité, Laboratoire CSPBAT, CNRS UMR 7244, 93017 Bobigny Cedex, France   eMail: julia.deschamp@univ-paris13.fr   eMail: marc.lecouvey@univ-paris13.fr
› Institutsangaben
Université Paris 13, Sorbonne Paris Cité, Centre National de la Recherche Scientifique (CNRS), Ministère de l’Enseignement Supérieur et de la Recherche (MESR), and GDR Phosphore (CNRS) are gratefully acknowledged for financial support.
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Publikationsverlauf

Received: 03. August 2018

Accepted: 20. August 2018

Publikationsdatum:
05.September 2018 (eFirst)

Abstract

A general synthetic procedure was developed for H-α-hydroxyphosphinates via Abramov reaction. The present work is a complementary study to those reported till now. This methodology has the advantage that it can be applied to various aliphatic and (hetero)aromatic substrates. The H-α-hydroxyphosphinates were easily purified and obtained in good to excellent yields in shorter times. A 31P NMR spectroscopy study has shown that only 2 equivalents of a silylating agent were required.

Supporting Information

 
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