Synthesis 2018; 50(22): 4471-4475
DOI: 10.1055/s-0037-1610087
paper
© Georg Thieme Verlag Stuttgart · New York

α-Arylation of Esters and Ketones Enabled by a Bench-Stable Pd(I) Dimer Catalyst

Theresa Sperger
,
Further Information

Publication History

Received: 24 April 2018

Accepted after revision: 16 May 2018

Publication Date:
25 June 2018 (eFirst)

Published as part of the Special Section dedicated to Scott E. Denmark on the occasion of his 65th birthday

Abstract

A procedure for the α-arylation of α,α-disubstituted esters and ketones to generate quaternary carbon centers is described. The developed protocol is operationally simple and employs an air- and moisture-stable dinuclear Pd(I) complex [Pd(μ-I)(Pt-Bu3)]2 to mediate selective α-arylation of aromatic C–I/Br bonds in the presence of aromatic C–Cl and/or C–OTf sites.

Supporting Information

 
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