CC BY ND NC 4.0 · SynOpen 2018; 02(02): 0096-0104
DOI: 10.1055/s-0037-1609449
review
Copyright with the author

Methods for Arylethylation of Amines and Heteroarenes

Department of Pharmacy – Center for Drug Research, Ludwig-Maximilians University, Butenandtstr. 5-13, 81377 Munich, Germany   Email: Franz.Bracher@cup.uni-muenchen.de
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Further Information

Publication History

Received: 21 February 2018

Accepted: 18 March 2018

Publication Date:
03 April 2018 (online)

Dedicated to my friend Norbert Breitschaft, who died on 7th of February, 2018.

Abstract

Compared with standard N-methylation, benzylation, and alkylation of amines and N-heterocycles, N-arylethylation is significantly more challenging. In this Review the available methods for N-arylethylation are summarized, with a special focus on efficiency, selectivity, availability of the required building blocks, and ecological aspects.

 
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