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Semin Neurol 2017; 37(06): 679-688
DOI: 10.1055/s-0037-1608881
Review Article
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Cerebrovascular Hemodynamics in Women

Cristina Duque
1   Division of Stroke and Neurocritical Care, Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, Illinois
2   Department of Neurology, Coimbra University Hospital Center, Coimbra, Portugal
,
Steven K. Feske
3   Division of Stroke, Department of Neurology, Brigham and Women's Hospital, Boston, Massachusetts
,
Farzaneh A. Sorond
1   Division of Stroke and Neurocritical Care, Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, Illinois
› Author Affiliations
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Publication History

Publication Date:
21 December 2017 (online)

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Abstract

Sex and gender, as biological and social factors, significantly influence health outcomes. Among the biological factors, sex differences in vascular physiology may be one specific mechanism contributing to the observed differences in clinical presentation, response to treatment, and clinical outcomes in several vascular disorders. This review focuses on the cerebrovascular bed and summarizes the existing literature on sex differences in cerebrovascular hemodynamics to highlight the knowledge deficit that exists in this domain. The available evidence is used to generate mechanistically plausible and testable hypotheses to underscore the unmet need in understanding sex-specific mechanisms as targets for more effective therapeutic and preventive strategies.

Keywords

cerebrovascular hemodynamics - women - cerebral autoregulation - cerebral vasoreactivity - neurovascular coupling
 

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