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Neuropediatrics 2018; 49(01): 051-058
DOI: 10.1055/s-0037-1608776
Original Article
Georg Thieme Verlag KG Stuttgart · New York

Multiple Sclerosis with Onset Younger Than 10 Years in Turkey

Zeynep Öztürk
1   Department of Pediatric Neurology, Gazi University, Faculty of Medicine, Ankara, Turkey
,
Ünsal Yılmaz
2   Department of Pediatric Neurology, Dr. Behçet Uz Children's Hospital, İzmir, Turkey
,
Bahadır Konuşkan
3   Department of Pediatric Neurology, Hacettepe University, Faculty of Medicine, Ankara, Turkey
,
Kıvılcım Gücüyener
1   Department of Pediatric Neurology, Gazi University, Faculty of Medicine, Ankara, Turkey
,
Ercan Demir
1   Department of Pediatric Neurology, Gazi University, Faculty of Medicine, Ankara, Turkey
,
Banu Anlar
3   Department of Pediatric Neurology, Hacettepe University, Faculty of Medicine, Ankara, Turkey
,
The Turkish Pediatric Multiple Sclerosis Study Group
› Author Affiliations
Further Information

Publication History

23 May 2017

02 October 2017

Publication Date:
28 November 2017 (online)

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Abstract

Objective To identify the demographics, clinical characteristics, disease course, treatment patterns, and disability levels of multiple sclerosis (MS) patients with onset under the age of 10 years (early onset multiple sclerosis, EOMS).

Methods EOMS patients were reviewed retrospectively in detailed records from 27 child neurology centers. Patients with preschool (≤7 years) and school age (>7 years) onset were compared.

Results There were 30 children (16 girls, 14 boys) who have disease onset between 4 and 10 (mean8.1 ± 1.8) years. MS was relapsing–remitting in 29 (96.7%) and primary progressive in one (3.3%) of the patients. In patients with onset ≤7 years, motor symptoms (54.5%) and encephalopathy (45.5%) predominated, while in those with onset >7 years brainstem (42.1%), sensory (26.3%), and optic nerve (26.3%) involvement were the most frequent presentations.

Conclusions MS starting ≤7 years differs from the 7–10–year-old group by the higher rate of motor symptoms and more attacks in the first year: the latter suggests a more inflammatory character for EOMS.

Keywords

Pediatric - multiple sclerosis - vitamin D - early onset - expanded disability status scale - relapse - magnetic resonance imaging

* See Appendix in the online supplementary material for a list of members of the Turkish Pediatric Multiple Sclerosis Study Group.


Note

Zeynep Ozturk wrote the first draft of manuscript. All co-authors read and agreed to the content. All co-authors checked and approved the submission of this version of the manuscript and take full responsibility of the manuscript. The authors declared no potential conflicts of interest with respect to the study design or manuscript preparation of this article.


Supplementary Material

 

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