Cranial Maxillofac Trauma Reconstruction
DOI: 10.1055/s-0037-1608699
Case Report
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Repair of Occipital Bone Defects in Neurofibromatosis Type 1 by Means of CAD/CAM Prefabricated Titanium Plates

Reinhard E. Friedrich
Department of Oral and Craniomaxillofacial Surgery, Eppendorf University Hospital, Hamburg, Germany
,
Pedram Emami
Department of Neurosurgery, Eppendorf University Hospital, Hamburg, Germany
,
Christian Hagel
Department of Neuropathology, Eppendorf University Hospital, Hamburg, Germany
,
Johannes Wikner
Department of Oral and Craniomaxillofacial Surgery, Eppendorf University Hospital, Hamburg, Germany
,
Henning Hanken
Department of Oral and Craniomaxillofacial Surgery, Eppendorf University Hospital, Hamburg, Germany
› Author Affiliations
Further Information

Publication History

01 June 2017

27 July 2017

Publication Date:
04 December 2017 (eFirst)

Abstract

Certain skeletal defects may develop in neurofibromatosis type 1 (NF1), a common tumor-suppressor syndrome, such as cranial lesions confined to the lambdoid suture region. Here, we report on the repair of osseous defects of occipital bone in a NF1 patient with history of skull trauma and tumorous hemorrhage. Computer-aided design and computer-aided manufacturing (CAD/CAM)-assisted devices were applied to safely close the bone defects. The variable phenotype of NF1 in the occipital skull region is discussed and a brief review is presented on NF1-related therapies for tumors and malformations of the occipitoparietal skull region.