Acute Toxicity, Phytochemical, and Antimicrobial Properties of Selected Nigeria Medicinal plants on Amoxicillin-resistant Microorganisms
24 October 2017 (online)
Antimicrobial studies were carried out on the aqueous methanolic extracts of stem bark of Zanthoxylum leprieurii, Anthocleistha vogelli, Mesembryanthemum crystallinum and leaves of Milletia aboensis. These plants find wide applications in African Traditional Medicinal Practice (ATMP). The plant materials were subjected to cold maceration using 95% methanol and the extracts concentrated in a rotary evaporator at 40 °C. Acute toxicity studies revealed that the plants have high safety margin with LD50 > 5000 g/Kg except M. Crystallinum which shows LD50 of 2900 g/Kg. Qualitative phytochemical analysis confirms the presence of most of the secondary plant metabolites on all the plants tested. Antimicrobial screening was carried out using agar diffusion method. All the extracts, except that of M. aboensis showed fairly good inhibitory zone diameters on most of the tested organisms with the activities residing mainly on the n-hexane fractions.