Planta Medica International Open 2017; 4(S 01): S1-S202
DOI: 10.1055/s-0037-1608449
Poster Session
Georg Thieme Verlag KG Stuttgart · New York

Neuroprotective Effect of 80% Methanol Extract of Lysimachia Christinae Hance in HT22 Cells

W Lee Hyeon
1   Department of Medical Biomaterials Engineering, College of Biomedical Science, Kangwon National University, Chuncheon, Korea, Republic of (South)
,
H Ryu Ga
1   Department of Medical Biomaterials Engineering, College of Biomedical Science, Kangwon National University, Chuncheon, Korea, Republic of (South)
,
S Yang Woo
1   Department of Medical Biomaterials Engineering, College of Biomedical Science, Kangwon National University, Chuncheon, Korea, Republic of (South)
,
J Ma Choong
1   Department of Medical Biomaterials Engineering, College of Biomedical Science, Kangwon National University, Chuncheon, Korea, Republic of (South)
2   Republic of Korea, 2Institute of Bioscience & Biotechnology, Kangwon National University, Chuncheon, Korea, Republic of (South)
› Author Affiliations
Further Information

Publication History

Publication Date:
24 October 2017 (online)

 

Lysimachia christinae Hance was traditionally used as Chinese traditional medicine. It is known to ease off the hyperuricemia and possess antipyretic and anti-inflammatory activity. Excessive glutamate contributes to excitotoxicity in brain and this can be etiological cause of the neurodegenerative diseases. The purpose of the study was to determine the neuroprotective effect of 80% methanol extract of Lysimachia christinae Hance against glutamate-induced oxidative stress in HT22 cells. In this experiment, intracelluar concentration of ROS and Ca2+ was decreased against glutamate treatment and this kept the normal mitochondrial membrane potential level. In addition, total glutathione amount and glutathione related antioxidant enzymes activities are increased. Through the whole mechanisms, Lysimachia christinae Hance significantly survived at the cell viability test. Consequently, Lysimachia christinae Hance is expected to be a good neuroprotective material.