Planta Medica International Open 2017; 4(S 01): S1-S202
DOI: 10.1055/s-0037-1608381
Poster Session
Georg Thieme Verlag KG Stuttgart · New York

LIPOSOME VEHICULATION OF THE ESSENTIAL OILS OF SALVIA TRILOBA AND ROSMARINUS OFFICINALIS FOR THE TOPICAL DELIVERY

L Risaliti
1   Department of Chemistry, University of Florence, Sesto Fiorentino, Italy
,
A Kehagia
2   Aristotle University of Thessaloniki, Department of Pharmacy, Thessaloniki, Greece
,
E Daoultzi
2   Aristotle University of Thessaloniki, Department of Pharmacy, Thessaloniki, Greece
,
D Lazzari
2   Aristotle University of Thessaloniki, Department of Pharmacy, Thessaloniki, Greece
,
C Bergonzi Maria
1   Department of Chemistry, University of Florence, Sesto Fiorentino, Italy
,
R Bilia Anna
1   Department of Chemistry, University of Florence, Sesto Fiorentino, Italy
› Author Affiliations
Further Information

Publication History

Publication Date:
24 October 2017 (online)

 

The vesicular systems represent useful strategies to improve the skin permeation of essential oils because of their instability to light and their volatile structure [1]. Essential oils have been widely used for their health and medicinal properties, principally as bactericidal, virucidal, fungicidal, insecticidal [2]. This study was focused on the development of versatile nanovesicles for the delivery of essential oils [3]. Liposomes were prepared and loaded with the essential oils of Salvia triloba and Rosmarinus officinalis. The essential oils were obtained by steam distillation and their main constituents were eucalyptol and camphor. The vesicles were prepared by Thin Layer Evaporation with a 1% v/v of oil. Nanocarrier batches were characterized for their size, polydispersity index, Zeta potential, recovery, encapsulation efficiency (EE%), release and morphology. Results showed that all liposomes exhibit average sizes about 200nm, the Z-potential varied from -35mV to -20 mV, the PDI was under 0,25, EE% were 56,71 ± 8,82% for S. triloba and 64,56 ± 8,41% for R. officinalis. The stability test was carried out, after storing at 4 °C for 20 days for S. triloba and R. officinalis, by monitoring changes in their mean size, PDI and EE% values. In addition, the Skin PAMPA test (Parallel Artificial Membrane Permeability Assay) which is highly predictive for skin permeation was carried out for the developed formulations. The findings suggest that these formulations can decrease the volatility of the essential oil and optimise the delivery inside the skin.

[1] Bilia AR, Guccione C, Isacchi B, Righeschi C, Firenzuoli F, Bergonzi MC. Evid Based Complement Alternat Med 2014:651593. doi: 10.1155/2014/651593.

[2] Bilia AR, Piazzini V, Guccione C, Risaliti L, Asprea M, Capecchi G, & Bergonzi MC. Planta Medica; 2017;83:366 – 381. doi: 10.1055/s-0043 – 102949.

[3] Asprea M, Leto I, Bergonzi M.C, Bilia A.R. LWT – Food Science and Technology, 2017; 77: 497 – 502.