Planta Medica International Open 2017; 4(S 01): S1-S202
DOI: 10.1055/s-0037-1608380
Poster Session
Georg Thieme Verlag KG Stuttgart · New York

Characterization of a Neurodifferentiation Inducing Flavonoid/Cyclodextrin Inclusion Complex

Authors

  • M Kirchinger

    1   Organic and Analytical Chemistry, S cience Center Straubing, Schulgasse 16 94315 Straubing, Straubing, Germany

  • L Bieler

    2   Institute of Experimental Neuroregeneration Paracelsus Medical University, Salzburg, Strubergasse 21, 5020 Salzburg, Salzburg, Austria

  • S Couillard-Despres

    2   Institute of Experimental Neuroregeneration Paracelsus Medical University, Salzburg, Strubergasse 21, 5020 Salzburg, Salzburg, Austria

  • H Riepl

    1   Organic and Analytical Chemistry, S cience Center Straubing, Schulgasse 16 94315 Straubing, Straubing, Germany

  • C Urmann

    1   Organic and Analytical Chemistry, S cience Center Straubing, Schulgasse 16 94315 Straubing, Straubing, Germany
Further Information

Publication History

Publication Date:
24 October 2017 (online)

 

Humulus lupulus L. is a well known traditional medicinal plant. Recently, pyranoflavonoids of hops were identified as potent inducers of neuronal differentiation in adult neuronal stem cells.[1,2] Unfortunately, the lipophilic side chain results in low water solubility and this makes an application in vivo difficult. To overcome this hurdle, (2-hydroxypropyl)-β-cyclodextrin is used to enhance solubility.

This cyclodextrine is water-soluble, non-toxic and has already been applied in numerous pharmaceutical preparations.[3] The maximum solubility of xanthohumol C in water is 2 µg/mL. Using cyclodextrin the solubility can be increased to 1300 µg/mL, confirmed by using HPLC analysis. In vitro, encapsulated xanthohumol C is as active as the pure flavonoid, making the cyclodextrin complex a suitable form of application for future in vivo studies.

[1] Oberbauer E, Urmann C, Steffenhagen C, Bieler L, Furtner T, Humpel C, Baumer B, Bandtlow C, Couillard-Despres S, Rivera FJ, Riepl H, Aigner L. Journal of Nutritional Biochemistry 2013, 24: 1953 – 1962.

[2] Urmann C, Oberbauer E, Couillard-Despres S, Aigner L, Riepl H. Planta Medica 2015, 4: 305 – 311.

[3] T. Irie, K. Uekama, Journal of pharmaceutical Science, 86 (1996) 147 – 162.