Planta Medica International Open 2017; 4(S 01): S1-S202
DOI: 10.1055/s-0037-1608142
Poster Session
Georg Thieme Verlag KG Stuttgart · New York

Benzoyltyramine Alkaloids Atalantums A-G with Their Cytotoxicity against Cholangiocarcinoma Cell Line from the Peels of Atalantia monophylla

Authors

  • T Sribuhom

    1   Natural Products Research Unit, Center of Excellence for Innovation in Chemistry, Department of Chemistry, Faculty of Science, Khon Kaen University, Khon Kaen 40002, Thailand, Khon Kaen, Thailand

  • P Boueroy

    2   Department of Microbiology, Liver Fluke and Cholangiocarcinoma Research Center, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand, Khon Kaen, Thailand

  • C Hahnvajanawong

    2   Department of Microbiology, Liver Fluke and Cholangiocarcinoma Research Center, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand, Khon Kaen, Thailand

  • R Phatchana

    3   Department of Chemistry, Faculty of Engineering, Rajamangala University of Technology Isan, Khon Kaen Campus, Khon Kaen 40000, Thailand, Khon Kaen, Thailand

  • C Yenjai

    1   Natural Products Research Unit, Center of Excellence for Innovation in Chemistry, Department of Chemistry, Faculty of Science, Khon Kaen University, Khon Kaen 40002, Thailand, Khon Kaen, Thailand
Further Information

Publication History

Publication Date:
24 October 2017 (online)

 

The extraction and isolation of the peels of Atalantia monophylla using chromatographic methods afforded seven new benzoyltyramines, atalantums A-G (1 – 7), along with five known compounds [1]. The structures of these compounds were elucidated based on the analysis of spectroscopic data. Compound 5 displayed the strongest cytotoxicity against KKU-M156 cells, with an IC50 value of 1.97 ± 0.73 µM, an approximately 4.7-fold higher activity than that of the ellipticine standard [2]. Compound 1 was active against KKU-M214 cells, with an IC50 value of 3.06 ± 0.51 µM. For KKU-M213 cell line, compounds 2, 4, and 11 displayed stronger cytotoxicity than the ellipticine standard, with IC50 values of 2.36 ± 0.20, 5.63 ± 0.22, and 2.71 ± 0.23 µM, respectively. Compounds 1, 5, and 7 displayed cytotoxicity against KKU-M214 cells, with IC50 values of 3.06 ± 0.51, 8.44 ± 0.47, and 7.37 ± 1.29 µM, respectively [3].

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Fig. 1

[1] Panda H. Handbook on Medicinal Herbs with Uses: Asia Pacific Business Press Inc; 2004: 166 – 167.

[2] Loilome W, Yongvanit P, Wongkham C, Tepsiri N, Sripa B, Sithithaworn P, Hanai S, Miwa M. Mol. Carcinog 2006; 45: 279 – 287.

[3] Sribuhom T, Boueroy P, Hahnvajanawong C, Phatchana R, Yenjai C. J. Nat. Prod 2017; 80: 403 – 408.