Benzoyltyramine Alkaloids Atalantums A-G with Their Cytotoxicity against Cholangiocarcinoma Cell Line from the Peels of Atalantia monophylla

The extraction and isolation of the peels of Atalantia monophylla using chromatographic methods afforded seven new benzoyltyramines, atalantums A-G (1 – 7), along with five known compounds [1]. The structures of these compounds were elucidated based on the analysis of spectroscopic data. Compound 5 displayed the strongest cytotoxicity against KKU-M156 cells, with an IC₅₀ value of 1.97 ± 0.73 µM, an approximately 4.7-fold higher activity than that of the ellipticine standard [2]. Compound 1 was active against KKU-M214 cells, with an IC₅₀ value of 3.06 ± 0.51 µM. For KKU-M213 cell line, compounds 2, 4, and 11 displayed stronger cytotoxicity than the ellipticine standard, with IC₅₀ values of 2.36 ± 0.20, 5.63 ± 0.22, and 2.71 ± 0.23 µM, respectively. Compounds 1, 5, and 7 displayed cytotoxicity against KKU-M214 cells, with IC₅₀ values of 3.06 ± 0.51, 8.44 ± 0.47, and 7.37 ± 1.29 µM, respectively [3].

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[1] Panda H. Handbook on Medicinal Herbs with Uses: Asia Pacific Business Press Inc; 2004: 166 – 167.

[2] Loilome W, Yongvanit P, Wongkham C, Tepsiri N, Sripa B, Sithithaworn P, Hanai S, Miwa M. Mol. Carcinog 2006; 45: 279 – 287.

[3] Sribuhom T, Boueroy P, Hahnvajanawong C, Phatchana R, Yenjai C. J. Nat. Prod 2017; 80: 403 – 408.