Planta Medica International Open 2017; 4(S 01): S1-S202
DOI: 10.1055/s-0037-1608111
Poster Session
Georg Thieme Verlag KG Stuttgart · New York

Isolation and biological evaluation of prenylated flavonoids from Maclura pomifera

S Ross
1   National Center for Natural Products Research, University of Mississippi, MS, University, United States
4   Department of BioMolecular Science, University of Mississippi, MS, University, United States
,
Y Orazbekov
1   National Center for Natural Products Research, University of Mississippi, MS, University, United States
2   Kazakh National Medical University, Almaty, Kazakhstan
3   South Kazakhstan Pharmaceutical Academy, Al-Farabi square, Shymkent, Kazakhstan
,
R Srivedavyasasri
1   National Center for Natural Products Research, University of Mississippi, MS, University, United States
,
S Mombekov
2   Kazakh National Medical University, Almaty, Kazakhstan
,
U Datkhayev
2   Kazakh National Medical University, Almaty, Kazakhstan
,
B Makhatov
3   South Kazakhstan Pharmaceutical Academy, Al-Farabi square, Shymkent, Kazakhstan
› Author Affiliations
Further Information

Publication History

Publication Date:
24 October 2017 (online)

 

Maclura pomifera (Moraceae), is native to Southwestern United States, and known as Osage orange. Various Maclura species are worldwide used in folkloric medicine [1]. M. pomifera and its components possess several biological activities including cytotoxic, antitumor, antibacterial, estrogenic, antifungal, antiviral and antimalarial activities [2 – 4]. Several prenylated flavonoids with potent pharmacological effects were previously reported from M. pomifera. Herein, we report the isolation, characterization, and biological evaluation of four new (I-IV) and nine known compounds: warangalone, auriculasin, osajin, pomiferin, artocarpesin, tonkinensisol, corchoionoside B, stigmasterol and β-sitosterol from the fruits of M. pomifera growing in Kazakhstan. The total extract showed significant activity towards cannabinoid receptors (CB1 – 103.4, CB2 – 68.8%displacement) and possibly allosteric towards δ and µ opioid receptors (-49.7, and -53.8%displacement, respectively). Compound I exhibited possible allosteric activity in κ and µ opioiod receptors (-88.4, -27.2% displacement, respectively), and showed moderate activity (60.5%displacement) towards CB1 receptor.

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Fig. 1

The project was supported by Kazakhstan government and National Center for Natural Product Research, USA. We would like to acknowledge Award Number P20GM104932 from the National Institute of General Medical Sciences, USA for bioassay results.

[1] Bourdy G, de Michel LRC, Roca-Coulhard A. J. Ethnopharmacol. 2004; 91: 189 – 208.

[2] Bunyapraphatsara N, Dechsree S, Yoosook C, Herunsalee A, Panpisutchai Y. Phytomedicine 2000; 6: 421 – 424.

[3] Peterson CF, Brockemeyer EW. Am. J. Pharm. Sci. Suppl. Pub. Hlth. 1953; 125: 303 – 310

[4] Jones JM, Soderberg F. Cell Immunol. 1979; 42: 319 – 326.