Planta Medica International Open 2017; 4(S 01): S1-S202
DOI: 10.1055/s-0037-1608091
Poster Session
Georg Thieme Verlag KG Stuttgart · New York

New Alkaloids from Taiwanese Zoanthid Palythoa tuberculosa

YB Cheng
1   Graduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University, Kaohsiung, Taiwan
2   Research Center for Natural Products & Drug Development, Kaohsiung Medical University, Kaohsiung, Taiwan
3   Center for Infectious Disease and Cancer Research, Kaohsiung Medical University, Kaohsiung, Taiwan
,
CJ Su
1   Graduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University, Kaohsiung, Taiwan
,
SR Chen
1   Graduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University, Kaohsiung, Taiwan
,
CY Chen
4   Department of Physical Therapy, Tzu-Hui Institute of Technology, Pingtung, Taiwan
› Author Affiliations
Further Information

Publication History

Publication Date:
24 October 2017 (online)

 

Zoanthid is a radial symmetry cnidarian with two rows of tentacles and is usually found on the rocky coast of subtropical and tropical areas. The various colors of zoanthids were due to the symbiotic relationships with single-celled zooxanthellae, such as dinoflagellates and green algae. Due to its fascinating colors, this sessile benthic organism often becomes ornamentals in aquariums. In addition, zoanthids are also regarded as rich sources of novel secondary metabolites with diverse bioactivities. For example, ecdysones isolated from Palythoa mutuki suppress dengue virus production [1], while alkaloids purified from Zoanthus kuroshio inhibit superoxide anion generation and elastase release [2]. In our bioactive screening of Taiwanese zoanthids, the high polarity fraction of Palythoa tuberculosa was found to have potent cytotoxic and moderate anti-inflammatory activities. Therefore, a series of bioassay-guided fractionation for these animal materials was carried out. The animal material of P. tuberculosa (4.0 kg) were extracted by ethanol and separated by consecutive column chromatography. As a result, three new pyrazines (13) and five known alkaloids (48) were isolated. The structures of all isolates were determined by analyzing their IR, Mass, NMR, and UV spectroscopic data. Cytotoxicity against a human breast cancer cell line (MDA-MB231) and anti-inflammatory activities of the isolated compounds were evaluated.

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Fig. 1

[1] Lee JC, Chang FR, Chen SR, Wu YH, Hu HC, Wu YC, Backlund A, Cheng YB. Marine Drugs 2016; 14: 151.

[2] Hsu YM, Chang FR, Lo IW, Lai KH, El-Shazly M, Wu TY, Du YC, Hwang TL, Cheng YB, YC Wu. J Nat Prod 2016; 79: 2674 – 2680