New Dioxopiperazine and peptide derivatives, isolated from the leaves of Breynia Nivosa.

In its first report, Chemical investigation of the ethylacetate fraction of the leaves of Breynia nivosa from the eastern part of Nigeria, led to the isolation of two new Dioxopiperazine derivatives,Breynivosin A (1), Breynivosin B (2) and two new peptides Breynivosamide A (4), Breynivosamide B (5) along with other seven known compounds, Asperphinamate (3), Cristatin A (6), breynioside A (7), Robostacide A (8), (E)-p- Coumaric acid (9), Blumenol A (10), and Ligodinolide (11),. Chemical characterization, with detailed interpretation of 1D and 2D NMR spectroscopic and mass spectrometry data analysis were used to establish the structures of these compounds. All compounds are isolated from this plant for the first time.