CC-BY-NC-ND 4.0 · Ind J Car Dis Wom 2017; 02(03): 007-013
DOI: 10.1055/s-0037-1607211
Review Article
Women in Cardiology and Related Sciences

Transcatheter Aortic Valve Replacement in Female Patients—Present Scenario

Osnat Itzhaki Ben Zadok1, Katia Orvin1, Ran Kornowski1
  • 1Department of Cardiology, Rabin Medical Center, and Sackler Faculty of Medicine, Tel Aviv University, Petah Tikva, Israel
Further Information

Publication History

Publication Date:
01 December 2017 (online)


Since the publication of the pivotal PARTNER study, the transcatheter aortic valve replacement (TAVR) procedure has been established as a noninferior alternative to the traditional aortic valve replacement surgery in severe aortic stenosis (AS) patients with high-surgical risk. Approximately 50% of patients undergoing TAVR are females, and cumulative findings from various worldwide cohorts have shown sex-related differences in short- and long-term morbidity and mortality. Notably, most data indicate improved long-term mortality in female patients. These differences are partly the results of distinct anatomical and physiologic characteristics in female patients, compared with male patients. Nevertheless, recent data from intermediate-surgical risk cohorts have demonstrated that sex-related mortality differences are less apparent. Here, we review the latest literature on the influence of patient's sex on TAVR morbidity and mortality and discuss possible explanations for the outcomes presented.