Abstract
Background Treatment for neonatal alloimmune thrombocytopenia (NAIT) primarily involves maternal
administration of intravenous immunoglobulin (IVIG) therapy and prednisone according
to protocols based on risk stratification. While IVIG is generally well tolerated,
hematologic side effects are a potential complication.
Case We present the successful management of a rare complication of maternal pancytopenia
following standard IVIG treatment. Diagnosis was made during routine obstetric exams.
Management included reducing IVIG dosage and adding daily prednisone. Additionally,
infusion Lots possibly associated with the event were identified and avoided. Interventions
resulted in the resolution of pancytopenia and the birth of a healthy infant without
thrombocytopenia.
Conclusion Pancytopenia is a rare complication of IVIG treatment in women with pregnancies complicated
by NAIT. Serial complete blood counts at the time of treatment would allow for early
detection and timely management of the patient. Additionally, limiting the number
of infusion Lots may decrease the chance of the described complications.
Keywords
NAIT - pancytopenia - IVIG - prednisone - blood count
