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Journal of Pediatric Neurology 2018; 16(03): 164-170
DOI: 10.1055/s-0037-1606380
Review Article
Georg Thieme Verlag KG Stuttgart · New York

First Presentation of an Acquired Demyelinating Syndrome

Rachel Gottlieb-Smith
1   Division of Child Neurology, Departments of Neurology and Pediatrics, Perelman School of Medicine at the University of Pennsylvania, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, United States
,
Amy T. Waldman
1   Division of Child Neurology, Departments of Neurology and Pediatrics, Perelman School of Medicine at the University of Pennsylvania, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, United States
› Author Affiliations
Further Information

Publication History

26 June 2017

25 July 2017

Publication Date:
08 September 2017 (online)

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Abstract

Acquired demyelinating syndromes (ADS) present with acute or subacute monofocal or polyfocal neurologic deficits localizing to the central nervous system. The clinical features of distinct ADS have been carefully characterized including optic neuritis, transverse myelitis, and acute disseminated encephalomyelitis. These disorders may all be monophasic disorders. Alternatively, optic neuritis, partial transverse myelitis, and acute disseminated encephalomyelitis may be first presentations of a relapsing or polyphasic neuroinflammatory disorder, such as multiple sclerosis or neuromyelitis optica. The clinical features of these disorders and the differential diagnosis are discussed in this article.

Keywords

optic neuritis - transverse myelitis - acute disseminated encephalomyelitis
 

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