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J Pediatr Infect Dis 2019; 14(03): 133-135
DOI: 10.1055/s-0037-1606341
Case Report
Georg Thieme Verlag KG Stuttgart · New York

A Fulminant Case of Haemophilus influenzae Serotype F Meningitis in an Immunocompetent 3-Year-Old Boy

Luise Wolf
1   Department of Women and Child Health, Hospital for Children and Adolescents, University Hospital Leipzig, Leipzig, Germany
,
Norman Lippmann
2   Institute for Medical Microbiology and Epidemiology of Infectious Diseases, Leipzig University Hospital, Leipzig, Germany
,
Stefanie Petzold-Quinque
1   Department of Women and Child Health, Hospital for Children and Adolescents, University Hospital Leipzig, Leipzig, Germany
,
Manuela Siekmeyer
1   Department of Women and Child Health, Hospital for Children and Adolescents, University Hospital Leipzig, Leipzig, Germany
,
Wieland Kieß
3   Department of Women and Child Health, Hospital for Children and Adolescents, Center for Pediatric Research, University Hospital Leipzig, Leipzig, Germany
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Publikationsverlauf

20. März 2017

25. Juli 2017

Publikationsdatum:
13. September 2017 (online)

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Abstract

Of all encapsulated Haemophilus influenzae (Hi), serotype b (Hib) is considered as the potentially most virulent one for children. After vaccination was introduced in the 1990s, the incidence of this serotype has dropped dramatically. Other encapsulated forms such as Hi serotype a, c, d, e, f (Hia-Hif) are diagnosed rarely and mostly affect vulnerable patient groups. As serotyping is not performed routinely, the number of unreported cases is estimated to be even higher. Whereas several cases of Hif disease in children with favorable outcome were published, a 3-year-old boy diagnosed with this serotype died at our hospital despite initial antimicrobial therapy.

Keywords

Haemophilus influenzae serotype f - bacterial meningitis - child - fatal outcome
 

  • References

  • 1 Agrawal A, Murphy TF. Haemophilus influenzae infections in the H. influenzae type b conjugate vaccine era. J Clin Microbiol 2011; 49 (11) 3728-3732
    CrossrefPubMedSuche in Google Scholar
  • 2 European Centre for Disease Prevention and Control. Surveillance of Invasive Bacterial Diseases in Europe, 2012. Stockholm, Sweden: European Centre for Disease Prevention and Control; 2015: 26-40
    Suche in Google Scholar
  • 3 Watt JP, Wolfson LJ, O'Brien KL. , et al; Hib and Pneumococcal Global Burden of Disease Study Team. Burden of disease caused by Haemophilus influenzae type b in children younger than 5 years: global estimates. Lancet 2009; 374 (9693): 903-911
    CrossrefPubMedSuche in Google Scholar
  • 4 Ladhani SN, Collins S, Vickers A. , et al. Invasive Haemophilus influenzae serotype e and f disease, England and Wales. Emerg Infect Dis 2012; 18 (05) 725-732
    CrossrefPubMedSuche in Google Scholar
  • 5 Robert Koch-Institut. Infektionsepidemiologisches Jahrbuch meldepflichtiger Krankheiten für 2014. Berlin, Germany: 2015: 88-92
    Suche in Google Scholar
  • 6 Giufrè M, Daprai L, Cardines R. , et al. Carriage of Haemophilus influenzae in the oropharynx of young children and molecular epidemiology of the isolates after fifteen years of H. influenzae type b vaccination in Italy. Vaccine 2015; 33 (46) 6227-6234
    CrossrefPubMedSuche in Google Scholar
  • 7 Su YC, Resman F, Hörhold F, Riesbeck K. Comparative genomic analysis reveals distinct genotypic features of the emerging pathogen Haemophilus influenzae type f. BMC Genomics 2014; 15: 38
    CrossrefPubMedSuche in Google Scholar
  • 8 Fickweiler K, Borte M, Fasshauer M, Spencker FB, Handrick W, Rodloff AC. Meningitis due to Haemophilus influenzae type f in an 8-year-old girl with congenital humoral immunodeficiency. Infection 2004; 32 (02) 112-115
    CrossrefPubMedSuche in Google Scholar
  • 9 Golebiewska A, Kuch A, Gawrońska A. , et al. Invasive Haemophilus influenzae serotype f case reports in Mazovia Province, Poland. Medicine (Baltimore) 2016; 95 (05) e2671
    PubMedSuche in Google Scholar
  • 10 Murphy TF. Vaccines for nontypeable Haemophilus influenzae: the future is now. Clin Vaccine Immunol 2015; 22 (05) 459-466
    CrossrefPubMedSuche in Google Scholar