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CC BY-NC-ND 4.0 · Arquivos Brasileiros de Neurocirurgia: Brazilian Neurosurgery 2017; 36(03): 185-189
DOI: 10.1055/s-0037-1606290
Case Report | Relato de Caso
Thieme Revinter Publicações Ltda Rio de Janeiro, Brazil

Neurosarcoidosis Associated with Psychiatric Symptoms: Case Report

Neurossarcoidose associada com sintomas psiquiátricos: relato de caso
Maick Wilen Fernandes Neves
1   Pontifícia Universidade Católica de Campinas (PUC-Campinas), Campinas, São Paulo, Brazil
,
Paulo Henrique Pires de Aguiar
2   Department of Neurosurgery, Hospital Santa Paula, São Paulo, São Paulo, Brazil
,
Telmo Augusto Barba Belsuzarri
3   Department of Neurosurgery, Hospital Celso Pierro, PUC Campinas, Campinas, São Paulo, Brazil
,
Wolnei Marques Zeviani
3   Department of Neurosurgery, Hospital Celso Pierro, PUC Campinas, Campinas, São Paulo, Brazil
,
João Flavio de Araújo Mattos
3   Department of Neurosurgery, Hospital Celso Pierro, PUC Campinas, Campinas, São Paulo, Brazil
,
Juliano Nery Navarro
3   Department of Neurosurgery, Hospital Celso Pierro, PUC Campinas, Campinas, São Paulo, Brazil
,
Renata de Melo Braga Marques
4   Hospital Celso Pierro, Pontifícia Universidade Católica de Campinas (PUC-Campinas), Campinas, São Paulo, Brazil
5   Centro de Atenção Integral à Saúde da Mulher (Caism), Universidade Estadual de Campinas (Unicamp), Campinas, São Paulo, Brazil
,
Letícia Marissol de Souza Francisco
4   Hospital Celso Pierro, Pontifícia Universidade Católica de Campinas (PUC-Campinas), Campinas, São Paulo, Brazil
› Author Affiliations
Further Information

Publication History

15 April 2017

18 July 2017

Publication Date:
24 August 2017 (online)

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Abstract

Background Sarcoidosis is a granulomatous disease predominant in women and black men that has inflammatory origin of unknown etiology; neurosarcoidosis is a rare and critical presentation of the disease.

Case description A 26-year-old black female presented frontal headache for 1 year, as well as behavioral and mood changes for 15 days. Skull tomography and nuclear magnetic imaging of the skull revealed damaged meninges, a right frontal bone lesion, and an intraparenchymal contrast-enhancing lesion. Screening with computed tomography (CT) scans was performed, and it showed signs of bronchiectasis in the lower third of the right lung, but it was asymptomatic. The biopsy showed signs of reactional lesion with the presence of non-caseating granulomas. After the treatment with corticosteroids, the patient presented progressive improvement.

Conclusions Neurosarcoidosis is a rare and critical pathology of sarcoidosis that presents a lytic bone lesion and clinical psychiatric symptoms; neurosarcoidosis is also rare in the literature.

Resumo

Introdução A sarcoidose é uma doença granulomatosa de origem inflamatória de etiologia desconhecida, predominante em mulheres e negros, sendo a neurosarcoidose uma apresentação da doença rara relacionada a gravidade.

Relato de Caso Paciente com 26 anos, negra, apresenta quadro cefaleia frontal ha 1 ano e há 15 dias apresentando sinais de alterações de comportamento e humor. Tomografia de crânio e Ressonância nucelar magnética de crânio que evidenciaram lesão óssea frontal direita, comprometimento meninges e lesão intraparenquimatosa captante de contraste. Realizado screening com tomografias que evidenciaram sinais de bronquiectasia em terço inferior pulmão direito, assintomática. Biopsia indicando sinais de lesão reacional com presenças de granulomas não caseosos, Após a manutenção da corticoterapia, a paciente apresentou melhora progressiva.

Conclusões A neurosarcoidose é uma patologia grave e rara da sarcoidose, nesse caso apresenta uma lesão óssea lítica e sintomas psiquiátricos, apresentação rara na literatura.

Keywords

sarcoidosis - neurosarcoidosis - psychiatric manifestations - pathology

Palavras-chave

sarcoidose - neurosarcoidose - manifestações psiquiátricas - patologia
 

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