Gesundheitswesen 2017; 79(08/09): 656-804
DOI: 10.1055/s-0037-1606004
Poster
Georg Thieme Verlag KG Stuttgart · New York

Association between four a priori-defined diet quality indices and lipid-soluble micronutrients in the Multietchni Cohort

N Aumüller
1   Institut für Medizinische Biometrie, Epidemiologie und Informatik (IMBEI), Mainz
2   University of Hawaii Cancer Center, Cancer Epidemiology, Honolulu
,
G Maskarinec
2   University of Hawaii Cancer Center, Cancer Epidemiology, Honolulu
,
CJ Boushey
2   University of Hawaii Cancer Center, Cancer Epidemiology, Honolulu
,
AA Franke
2   University of Hawaii Cancer Center, Cancer Epidemiology, Honolulu
,
YB Shvetsov
2   University of Hawaii Cancer Center, Cancer Epidemiology, Honolulu
,
L Le Marchand
2   University of Hawaii Cancer Center, Cancer Epidemiology, Honolulu
› Author Affiliations
Further Information

Publication History

Publication Date:
01 September 2017 (online)

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Introduction:

Dietary patterns have been associated with lower risk of several chronic diseases, but little is known about potential physiological mechanisms of this relation. We examined the association of a priori- defined diet quality indices and lipid-soluble micronutrients in serum collected from members of the Multiethnic Cohort (MEC) to elucidate potential physiological mechanisms.

Methods:

Dietary intake from more than 215,000 participants was assessed at baseline (1993 – 1996) using a validated quantitative food frequency questionnaire. The studied biomarkers (carotenoids, tocopherols, retinol, and coenzyme Q10) were measured in 2001 – 2006 in a biomarker subcohort (n = 8,367) using standard assays. Generalized linear models were applied and covariate-adjusted means of biomarkers were calculated for tertiles of 4 dietary indices: Healthy Eating Index 2010 (HEI 2010), the Alternative HEI 2010 (AHEI 2010), the Alternate Mediterranean Diet Score (aMED) and the Dietary Approaches to Stop Hypertension (DASH).

Results:

Participants with the highest diet quality had significantly higher serum concentrations of all 17 carotenoids, total tocopherols, and α-tocopherol, while γ-tocopherol was inversely associated with diet quality. Adjusted means for the lowest tertile of HEI 2010 compared to the highest were 1.2 vs. 1.5 ng/l (ptrend< 0.0001) for total carotenoids, 11.4 vs. 12.3 ng/l (ptrend< 0.0001) for total tocopherols, and 1.9 vs. 1.6 ng/l (ptrend< 0.0001) for γ-tocopherol. Similar differences were found for the other dietary indices.

Conclusion:

These results show an association of diet quality as assessed by HEI 2010, AHEI 2010, aMED, and DASH with carotenoids and tocopherols, which points to potential physiological mechanisms of the effect of diet quality on chronic disease risk. In addition, these biomarkers may be useful for assessing adherence to dietary patterns.

FUNDING SOURCE: US NIH/NCI (U01CA164973), PROMOS, and Susanne Marie Sofie Haufen-foundation.