Z Gastroenterol 2017; 55(08): e57-e299
DOI: 10.1055/s-0037-1604874
Kurzvorträge
Dünndarm und Dickdarm, Proktologie
Mikrobiotika in Pathogenese und Therapie: Freitag, 15 September 2017, 14:45 – 16:13, Rotterdam/Forschungsforum 2
Georg Thieme Verlag KG Stuttgart · New York

Gut microbiota induce local and systemic CD4 T cell responses in healthy individuals that are altered in inflammatory bowel diseases

, Oxford IBD Cohort Investigators
AN Hegazy
1   University of Oxford, Translational Gastroenterology Unit, Oxford, Vereinigtes Königreich
2   University of Oxford, Kennedy Institute of Rheumatology, Oxford, Vereinigtes Königreich
3   Charité – Universitätsmedizin Berlin, CBF, Medizinische Klinik I m.S. Gastroenterologie, Infektiologie und Rheumatologie, Berlin, Deutschland
,
N West
1   University of Oxford, Translational Gastroenterology Unit, Oxford, Vereinigtes Königreich
2   University of Oxford, Kennedy Institute of Rheumatology, Oxford, Vereinigtes Königreich
,
MJT Stubbington
4   European Bioinformatics Institute, European Molecular Biology Laboratory, Cambridge, Vereinigtes Königreich
5   Wellcome Trust Sanger Institute, Cambridge, Vereinigtes Königreich
,
E Wendt
1   University of Oxford, Translational Gastroenterology Unit, Oxford, Vereinigtes Königreich
,
K Suijker
2   University of Oxford, Kennedy Institute of Rheumatology, Oxford, Vereinigtes Königreich
,
A Datsi
1   University of Oxford, Translational Gastroenterology Unit, Oxford, Vereinigtes Königreich
,
S This
1   University of Oxford, Translational Gastroenterology Unit, Oxford, Vereinigtes Königreich
,
C Danne
2   University of Oxford, Kennedy Institute of Rheumatology, Oxford, Vereinigtes Königreich
,
S Campion
6   University of Oxford, Nuffield Department of Medicine Research Building, Oxford, Vereinigtes Königreich
,
SH Duncan
7   University of Aberdeen, Rowett Institute of Nutrition and Health, Aberdeen, Vereinigtes Königreich
,
HH Uhlig
8   University of Oxford, Department of Paediatrics, Oxford, Vereinigtes Königreich
,
BMJ Owens
1   University of Oxford, Translational Gastroenterology Unit, Oxford, Vereinigtes Königreich
,
A McMichael
6   University of Oxford, Nuffield Department of Medicine Research Building, Oxford, Vereinigtes Königreich
,
A Bergthaler
9   CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Österreich
,
SA Teichmann
4   European Bioinformatics Institute, European Molecular Biology Laboratory, Cambridge, Vereinigtes Königreich
5   Wellcome Trust Sanger Institute, Cambridge, Vereinigtes Königreich
,
S Keshav
1   University of Oxford, Translational Gastroenterology Unit, Oxford, Vereinigtes Königreich
,
F Powrie
1   University of Oxford, Translational Gastroenterology Unit, Oxford, Vereinigtes Königreich
2   University of Oxford, Kennedy Institute of Rheumatology, Oxford, Vereinigtes Königreich
› Author Affiliations
Further Information

Publication History

Publication Date:
02 August 2017 (online)

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Sensing of commensal microbes and their metabolites by the host immune system plays an important homeostatic role, but active systemic responses to the same commensals are thought to be rare and tightly regulated. Here we report that CD4+ T cells with reactivity towards intestinal microbiota are abundant in the circulation and enriched in the intestinal mucosa of healthy adults. Microbiota-specific memory T cells have a diverse TCRVβ repertoire and are a functionally heterogeneous population with Th17 and Th1 characteristics. These cells accumulate in the intestine of patients with inflammatory bowel disease and show enhanced interleukin-17A production driven by the altered cytokine milieu. Thus, gut microbiota-specific CD4+ T cells are part of the normal human T cell repertoire and do not necessarily indicate disturbed host-microbiota interactions. T cell responses to commensals may therefore support local and systemic immune responses by generating a plethora of memory T cells reactive to pathogens.